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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7-8
|
pubmed:dateCreated |
1993-1-15
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pubmed:abstractText |
Two vaccine preparations obtained from Bordetella pertussis, whole-cell vaccine constituting one of the components of adsorbed DPT vaccine and acellular vaccine, were tested for mutagenicity. The doses of the preparations covered the range 1-100 ED50. Ames' test and the metaphase analysis of marrow cells of C57BL/6J mice were used. The acellular preparation was also tested on thymectomized mice, taking into consideration chromosomal aberrations in marrow metaphases. Whole-cell and acellular pertussis vaccines did not induce mutations in Salmonella typhimurium and chromosomal aberrations in mouse marrow cells.
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pubmed:language |
rus
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0372-9311
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
42-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1466172-Animals,
pubmed-meshheading:1466172-Bone Marrow,
pubmed-meshheading:1466172-Chromosome Aberrations,
pubmed-meshheading:1466172-Dose-Response Relationship, Drug,
pubmed-meshheading:1466172-Genes, Bacterial,
pubmed-meshheading:1466172-Male,
pubmed-meshheading:1466172-Mice,
pubmed-meshheading:1466172-Mice, Inbred C57BL,
pubmed-meshheading:1466172-Mutagenesis,
pubmed-meshheading:1466172-Mutagenicity Tests,
pubmed-meshheading:1466172-Pertussis Vaccine,
pubmed-meshheading:1466172-Salmonella typhimurium,
pubmed-meshheading:1466172-Vaccines, Inactivated
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pubmed:year |
1992
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pubmed:articleTitle |
[The evaluation of the mutagenic activity of pertussis vaccinal preparations].
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
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