Source:http://linkedlifedata.com/resource/pubmed/id/14661079
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2004-2-3
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pubmed:abstractText |
Factors predisposing to the phenotypic features of higher total cholesterol (T-Cho) have not been clearly defined. Here we report an association between a C/T single nucleotide polymorphism at IVS17+8 in the inter-alpha-trypsin inhibitor heavy chain 4 gene (ITIH4) and plasma total cholesterol levels in 351 adult individuals from an east-central area of Japan. Age and gender-adjusted levels of plasma T-Cho, LDL-cholesterol, triglyceride, and HDL-cholesterol were analyzed. When we separate the subjects into two genotypic groups regarding this single nucleotide polymorphism (SNP), those who lack the T-allele had significantly higher plasma T-Cho levels than the others who bear T-allele (mean 252.3 mg/dl versus 241.7 mg/dl; p=0.009). Of the 309 individuals without the T-allele, approximately 90% presented with hypercholesterolemia, whereas only 10% were hypercholesterolemic among 42 individuals with the T-allele (p <0.0001). These data suggest that genetic variation at ITIH4 locus is one of the likely candidate determinants for plasma cholesterol metabolisms.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1434-5161
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pubmed:author |
pubmed-author:BujoHideakiH,
pubmed-author:EmiMitsuruM,
pubmed-author:EzuraYoichiY,
pubmed-author:FujitaYukoY,
pubmed-author:IinoYasuhikoY,
pubmed-author:KamimuraKouheiK,
pubmed-author:KatayamaYasuoY,
pubmed-author:SaitoYasushiY,
pubmed-author:SatoKeikoK,
pubmed-author:TakadaDaisukeD,
pubmed-author:TakahashiKaneoK
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
24-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:14661079-Aged,
pubmed-meshheading:14661079-Alpha-Globulins,
pubmed-meshheading:14661079-Analysis of Variance,
pubmed-meshheading:14661079-Cholesterol,
pubmed-meshheading:14661079-Chromosomes, Human, Pair 3,
pubmed-meshheading:14661079-Cohort Studies,
pubmed-meshheading:14661079-Female,
pubmed-meshheading:14661079-Genetic Variation,
pubmed-meshheading:14661079-Humans,
pubmed-meshheading:14661079-Hypercholesterolemia,
pubmed-meshheading:14661079-Japan,
pubmed-meshheading:14661079-Male,
pubmed-meshheading:14661079-Middle Aged,
pubmed-meshheading:14661079-Polymorphism, Single Nucleotide,
pubmed-meshheading:14661079-Serine Proteinase Inhibitors
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pubmed:year |
2004
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pubmed:articleTitle |
Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.
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pubmed:affiliation |
Department of Molecular Biology-Institute of Gerontology and Department of Internal Medicine II, Nippon Medical School, Kawasaki, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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