Linked Life Data

14659975

Source:http://linkedlifedata.com/resource/pubmed/id/14659975

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2003-12-8
pubmed:abstractText
Pheochromocytomas are well-vascularized tumors, suggesting that a potent angiogenic factor may be involved in the mechanism of their formation. As vascular endothelial growth factor (VEGF) is a potent mitogen for vascular endothelial cells, here we have investigated the mRNA and protein expression of VEGF and the mRNA expression of its two receptors (Flt-1 and Flk-1/KDR) in pheochromocytomas tissue. An increase in VEGF mRNA (mainly isoforms VEGF(121) and VEGF(165)) and in VEGF protein expression were observed by semi-quantitative RT-PCR and Western blot, respectively, compared to normal adrenomedullary tissue. Flk-1/KDR, and Flt-1 levels of mRNA were also increased markedly in tumors and correlated with levels of VEGF mRNA. Therefore, we speculate that upregulation of VEGF expression and its receptors might be important in the pathogenesis of pheochromocytomas.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
863-71
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:14659975-Adrenal Gland Neoplasms, pubmed-meshheading:14659975-Adrenal Glands, pubmed-meshheading:14659975-Blotting, Western, pubmed-meshheading:14659975-DNA Primers, pubmed-meshheading:14659975-Extracellular Matrix Proteins, pubmed-meshheading:14659975-Gene Expression Regulation, Neoplastic, pubmed-meshheading:14659975-Humans, pubmed-meshheading:14659975-Pheochromocytoma, pubmed-meshheading:14659975-Protein Isoforms, pubmed-meshheading:14659975-RNA, Messenger, pubmed-meshheading:14659975-RNA, Neoplasm, pubmed-meshheading:14659975-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:14659975-Up-Regulation, pubmed-meshheading:14659975-Vascular Endothelial Growth Factor A, pubmed-meshheading:14659975-Vascular Endothelial Growth Factor Receptor-1, pubmed-meshheading:14659975-Vascular Endothelial Growth Factor Receptor-2
pubmed:year
2004
pubmed:articleTitle
Expression of vascular endothelial growth factor (VEGF) and its cognate receptors in human pheochromocytomas.
pubmed:affiliation
Department of Clinical Pathology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan. K-takemd@md.tsukuba.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't