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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-12-8
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|
pubmed:abstractText |
Appetite-suppressant drug fenfluramine is implicated in primary pulmonary hypertension (PPH) but the molecular pathways that mediate this effect are unknown. A mouse model incriminates the serotonin 5-HT(2B) receptor but contrasts with other models where this receptor has been shown to mediate pulmonary arterial relaxation via nitric oxide production.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0008-6363
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
518-28
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14659797-Animals,
pubmed-meshheading:14659797-Appetite Depressants,
pubmed-meshheading:14659797-CHO Cells,
pubmed-meshheading:14659797-COS Cells,
pubmed-meshheading:14659797-Calcium,
pubmed-meshheading:14659797-Case-Control Studies,
pubmed-meshheading:14659797-Cell Membrane,
pubmed-meshheading:14659797-Cricetinae,
pubmed-meshheading:14659797-DNA Mutational Analysis,
pubmed-meshheading:14659797-Female,
pubmed-meshheading:14659797-Fenfluramine,
pubmed-meshheading:14659797-Flow Cytometry,
pubmed-meshheading:14659797-Humans,
pubmed-meshheading:14659797-Hypertension, Pulmonary,
pubmed-meshheading:14659797-Male,
pubmed-meshheading:14659797-Receptor, Serotonin, 5-HT2B
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pubmed:year |
2003
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pubmed:articleTitle |
Serotonin 5-HT(2B) receptor loss of function mutation in a patient with fenfluramine-associated primary pulmonary hypertension.
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pubmed:affiliation |
Service de Génétique Médicale, Université Libre de Bruxelles, 808 Lennik, B-1070 Brussels, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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