Linked Life Data

14657231

Source:http://linkedlifedata.com/resource/pubmed/id/14657231

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-12-9
pubmed:abstractText
The cell adhesion molecule L1 (L1-CAM) plays critical roles in neurite growth. Its cytoplasmic domain (L1CD) binds to ankyrins that associate with the spectrin-actin network. This paper demonstrates that L1-CAM interactions with ankyrinB (but not with ankyrinG) are involved in the initial formation of neurites. In the membranous protrusions surrounding the soma before neuritogenesis, filamentous actin (F-actin) and ankyrinB continuously move toward the soma (retrograde flow). Bead-tracking experiments show that ankyrinB mediates L1-CAM coupling with retrograde F-actin flow in these perisomatic structures. Ligation of the L1-CAM ectodomain by an immobile substrate induces L1CD-ankyrinB binding and the formation of stationary ankyrinB clusters. Neurite initiation preferentially occurs at the site of these clusters. In contrast, ankyrinB is involved neither in L1-CAM coupling with F-actin flow in growth cones nor in L1-based neurite elongation. Our results indicate that ankyrinB promotes neurite initiation by acting as a component of the clutch module that transmits traction force generated by F-actin flow to the extracellular substrate via L1-CAM.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-10462518, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-10550057, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-10608864, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-10662501, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-10871287, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-10871626, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-10934316, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-11035015, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-11045004, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-11163135, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-11222639, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-11717353, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-11753368, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-11781319, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-12070130, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-12077189, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-12082080, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-12105186, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-12499360, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-12925712, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-1429889, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-1769655, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-2324197, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-2627381, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-2940347, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-3025222, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-3078414, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-3136168, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-7531986, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-7536426, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-7931345, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-7962069, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-8283245, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-8608590, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-8794861, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-8956051, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9151675, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9211984, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9354804, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9450954, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9530493, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9531561, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9570805, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9580664, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9591694, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9638342, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9660878, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9695809, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9804856, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9832557, http://linkedlifedata.com/resource/pubmed/commentcorrection/14657231-9832558
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
163
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1077-88
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...