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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
35
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pubmed:dateCreated |
2003-12-5
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pubmed:abstractText |
Activation of cannabinoid CB1 receptors reduces glutamatergic synaptic transmission in the rodent striatum and is involved in the normal control of motor function by the basal ganglia. Here we investigated CB1 receptor regulation of glutamate release and uptake and synaptic transmission in the rat striatum. We show that CB1 receptor activation reduces both the release and uptake of [3H]glutamate in striatal slices. We also demonstrate that both activation of CB1 receptors and inhibition of glutamate uptake reduce corticostriatal synaptic transmission in a mutually occlusive manner and that both forms of depression are dependent on metabotropic glutamate receptor (mGluR) activation. We propose that CB1 receptor activation in the striatum decreases glutamate transporter activity and that the resulting increase in synaptic cleft glutamate concentration causes the activation of presynaptic mGluRs, which then decrease glutamate release.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AM 251,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Cannabinoids,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/LY 341495,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cannabinoid, CB1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydrocannabinol,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthenes,
http://linkedlifedata.com/resource/pubmed/chemical/rimonabant
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1529-2401
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
3
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11073-7
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pubmed:dateRevised |
2007-10-17
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pubmed:meshHeading |
pubmed-meshheading:14657164-Amino Acids,
pubmed-meshheading:14657164-Animals,
pubmed-meshheading:14657164-Cannabinoids,
pubmed-meshheading:14657164-Cerebral Cortex,
pubmed-meshheading:14657164-Corpus Striatum,
pubmed-meshheading:14657164-Glutamic Acid,
pubmed-meshheading:14657164-Male,
pubmed-meshheading:14657164-Neural Inhibition,
pubmed-meshheading:14657164-Piperidines,
pubmed-meshheading:14657164-Pyrazoles,
pubmed-meshheading:14657164-Rats,
pubmed-meshheading:14657164-Rats, Sprague-Dawley,
pubmed-meshheading:14657164-Receptor, Cannabinoid, CB1,
pubmed-meshheading:14657164-Receptors, Metabotropic Glutamate,
pubmed-meshheading:14657164-Synaptic Transmission,
pubmed-meshheading:14657164-Tetrahydrocannabinol,
pubmed-meshheading:14657164-Xanthenes
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pubmed:year |
2003
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pubmed:articleTitle |
Cannabinoids decrease corticostriatal synaptic transmission via an effect on glutamate uptake.
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pubmed:affiliation |
School of Biological Sciences, University of Manchester, Manchester, M13 9PT, United Kingdom.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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