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pubmed-article:14656087pubmed:abstractTextThe unprecedented application of unmodified aldehydes as nucleophilic donors in direct catalytic asymmetric Mannich-type reactions is disclosed in a full account. Our efforts in broadening the applicability of chiral pyrrolidine-based catalysts in direct asymmetric Mannich-type reactions led to the highly diastereo- and enantioselective and concise synthesis of functionalized alpha- and beta-amino acids, beta-lactams, and amino alcohols.lld:pubmed
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pubmed-article:14656087pubmed:articleTitleThe direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles.lld:pubmed
pubmed-article:14656087pubmed:affiliationThe Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.lld:pubmed
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