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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25
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pubmed:dateCreated |
2003-12-5
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pubmed:abstractText |
The unprecedented application of unmodified aldehydes as nucleophilic donors in direct catalytic asymmetric Mannich-type reactions is disclosed in a full account. Our efforts in broadening the applicability of chiral pyrrolidine-based catalysts in direct asymmetric Mannich-type reactions led to the highly diastereo- and enantioselective and concise synthesis of functionalized alpha- and beta-amino acids, beta-lactams, and amino alcohols.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-3263
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9624-34
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14656087-Aldehydes,
pubmed-meshheading:14656087-Amino Acids,
pubmed-meshheading:14656087-Amino Alcohols,
pubmed-meshheading:14656087-Catalysis,
pubmed-meshheading:14656087-Dioxanes,
pubmed-meshheading:14656087-Imines,
pubmed-meshheading:14656087-Lactams,
pubmed-meshheading:14656087-Mannich Bases,
pubmed-meshheading:14656087-Models, Chemical,
pubmed-meshheading:14656087-Proline,
pubmed-meshheading:14656087-Pyrrolidines,
pubmed-meshheading:14656087-Solvents,
pubmed-meshheading:14656087-Stereoisomerism,
pubmed-meshheading:14656087-Structure-Activity Relationship
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pubmed:year |
2003
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pubmed:articleTitle |
The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles.
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pubmed:affiliation |
The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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