Linked Life Data

1465480

Source:http://linkedlifedata.com/resource/pubmed/id/1465480

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-1-15
pubmed:abstractText
The RNA-dependent P1/eIF-2 alpha protein kinase is a highly specific protein-serine/threonine kinase that catalyzes the phosphorylation of the alpha subunit of protein synthesis initiation factor eIF-2. The kinase plays a central role in translational control. The activity of the kinase is regulated by a variety of naturally occurring effector RNAs which bind to the regulatory domain of the enzyme. Certain RNAs are able to activate the eIF-2 alpha kinase activity inherent within protein P1, a process which involves an autophosphorylation of protein P1, whereas other RNAs are able to antagonize the activation process. Translational repression mediated by the kinase may also be disrupted by RNA binding proteins that sequester activator double-stranded RNAs and by site-directed mutants and homologs of the eIF-2 alpha translation factor substrate. The P1/eIF-2 alpha protein kinase is an important regulator of the translation of plasmid-derived mRNAs in transfected eukaryotic cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0163-7258
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
307-17
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Role of the RNA-dependent protein kinase in the regulated expression of genes in transfected cells.
pubmed:affiliation
Department of Biological Sciences, University of California, Santa Barbara 93106.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review