Source:http://linkedlifedata.com/resource/pubmed/id/14654791
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
55
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pubmed:dateCreated |
2003-12-5
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pubmed:abstractText |
B-cell lymphoma gene (BCL-6) upregulation contributes to immortalization of mouse embryo fibroblast and primary B cells via upregulation of cyclin D1. As cyclin D1 overexpression is a common phenomenon in different cancers, BCL-6 protein overexpression may not be restricted to lymphomas. In this study, expression of BCL-6 was investigated by immunohistochemistry on paraffin-embedded specimens from 150 breast cancer patients and 10 specimens of normal breast tissue. The results showed BCL-6 overexpression (> or =10% of cells) in 24/150 (16%) breast cancer patients, whereas in normal breast low expression (<1%) of BCL-6 was observed. In linear regression analysis BCL-6 expression was associated with cyclin D1 (r=0.197, P=0.016). Further, in chi2 analyses, BCL-6-positivity was associated with overexpression of p53 (P=0.016), and hypoxia-inducible factor-1alpha (P<0.001). Involvement of BCL-6 in breast carcinogenesis is further underscored by comparative genomic hybridization analysis that showed gains at the BCL-6 locus (3q27) in 14/86 (16%) breast cancer tissues. The cases with amplification in BCL-6 showed an increased (25%) incidence of BCL-6 protein overexpression. Thus, this study is the first to show that BCL-6 oncogene activation plays a role in cancers other than lymphomas.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D1,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HIF1A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-6,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0950-9232
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pubmed:author |
pubmed-author:BaakJan P AJP,
pubmed-author:BosReinhardR,
pubmed-author:GreijerAstrid EAE,
pubmed-author:HeijnenIngridI,
pubmed-author:HermsenMario A J AMA,
pubmed-author:MeijerGerrit AGA,
pubmed-author:PinedoHerbert MHM,
pubmed-author:ShvartsAviA,
pubmed-author:van DiestPaul JPJ,
pubmed-author:van der GroepPetraP,
pubmed-author:van der WallElskenE
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8948-51
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14654791-Breast Neoplasms,
pubmed-meshheading:14654791-Carcinoma, Ductal,
pubmed-meshheading:14654791-Carcinoma, Ductal, Breast,
pubmed-meshheading:14654791-Cyclin D1,
pubmed-meshheading:14654791-DNA-Binding Proteins,
pubmed-meshheading:14654791-Female,
pubmed-meshheading:14654791-Humans,
pubmed-meshheading:14654791-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:14654791-Immunohistochemistry,
pubmed-meshheading:14654791-Proto-Oncogene Proteins,
pubmed-meshheading:14654791-Proto-Oncogene Proteins c-bcl-6,
pubmed-meshheading:14654791-Transcription Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1alpha (HIF-1alpha).
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pubmed:affiliation |
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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