Source:http://linkedlifedata.com/resource/pubmed/id/14654715
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2003-12-5
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| pubmed:abstractText |
Adipocyte-derived leucine aminopeptidase (A-LAP) is a novel zinc-metallopeptidase involved in angiotensin II (AngII) metabolism, cell migration and antigen presentation. These functions are implicated in the progression of cancer, whereas A-LAP expression and involvement have not been studied in any type of cancer. We investigated the expression of A-LAP in endometrial cancer as well as its association with angiogenesis and clinicopathological features. Immunohistochemical staining of 58 endometrial endometrioid adenocarcinoma specimens revealed that 37 were A-LAP immunoreactive. We also found that A-LAP staining correlated with histological tumor grade in a significant and reverse manner. In addition, serum CA-125 levels in patients with A-LAP positive cancers were significantly higher. However, contrary to our hypothesis that A-LAP suppresses angiogenic activity via AngII metabolism, A-LAP expression was not associated with the microvessel count determined by CD34 immunostaining. Our results suggest that A-LAP is involved in endometrial cancer cell growth and differentiation. However, further studies, especially of the biological roles of A-LAP, are required to confirm this notion.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1010-4283
|
| pubmed:author |
pubmed-author:HattoriAkiraA,
pubmed-author:InoKazuhikoK,
pubmed-author:ItoNorioN,
pubmed-author:ItoTomomiT,
pubmed-author:KajiyamaHiroakiH,
pubmed-author:KazetoHideoH,
pubmed-author:KikkawaFumitakaF,
pubmed-author:MizutaniShigehikoS,
pubmed-author:NagasakaTetsuroT,
pubmed-author:NomuraSeijiS,
pubmed-author:ShibataKiyosumiK,
pubmed-author:TamakoshiKojiK,
pubmed-author:TsujimotoMasafumiM,
pubmed-author:WatanabeYoshiteruY
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| pubmed:copyrightInfo |
Copyright 2003 S. Karger AG, Basel
|
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
203-8
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:14654715-Adipocytes,
pubmed-meshheading:14654715-CA-125 Antigen,
pubmed-meshheading:14654715-Endometrial Neoplasms,
pubmed-meshheading:14654715-Female,
pubmed-meshheading:14654715-Humans,
pubmed-meshheading:14654715-Immunohistochemistry,
pubmed-meshheading:14654715-Leucyl Aminopeptidase,
pubmed-meshheading:14654715-Neoplasm Staging
|
| pubmed:articleTitle |
Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer. Association with tumor grade and CA-125.
|
| pubmed:affiliation |
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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| pubmed:publicationType |
Journal Article
|