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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2003-12-5
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pubmed:abstractText |
The purpose of this study was to evaluate the effect of the receptor tyrosine kinase inhibitor SU11654 on the activity of its molecular target KIT in canine mast cell tumors (MCT) and correlate target inhibition with mutational status of the c-kit juxtamembrane domain and SU11654 plasma concentration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5729-34
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:14654558-Animals,
pubmed-meshheading:14654558-Dog Diseases,
pubmed-meshheading:14654558-Dogs,
pubmed-meshheading:14654558-Enzyme Inhibitors,
pubmed-meshheading:14654558-Indoles,
pubmed-meshheading:14654558-Mast Cells,
pubmed-meshheading:14654558-Mast-Cell Sarcoma,
pubmed-meshheading:14654558-Mitogen-Activated Protein Kinases,
pubmed-meshheading:14654558-Neoplasm Metastasis,
pubmed-meshheading:14654558-Phosphorylation,
pubmed-meshheading:14654558-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:14654558-Pyrroles,
pubmed-meshheading:14654558-Recurrence
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pubmed:year |
2003
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pubmed:articleTitle |
Proof of target for SU11654: inhibition of KIT phosphorylation in canine mast cell tumors.
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pubmed:affiliation |
SUGEN, Inc., South San Francisco, California 94080, USA. npryer@ravenbio.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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