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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-12-5
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pubmed:abstractText |
In myelodysplastic syndromes (MDS) a normal karyotype by cytogenetic analysis (CA) corresponds to a low cytogenetic risk for acute myeloid leukaemia (AML) evolution, a subset of patients however develops AML. We evaluated the use of interphase fluorescence in situ hybridisation (I-FISH) in 31 patients with evolution from primary MDS to AML and a normal CA at all stages of disease. Monosomy 7 was found in 4/31 cases, one patient had a terminal deletion 5q, each after AML evolution. The low frequency and unclear prognostic value of I-FISH anomalies in MDS related AML suggests that these alterations play a minor role for AML evolution.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0145-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
171-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14654082-Acute Disease,
pubmed-meshheading:14654082-Adult,
pubmed-meshheading:14654082-Aged,
pubmed-meshheading:14654082-Aged, 80 and over,
pubmed-meshheading:14654082-Cell Transformation, Neoplastic,
pubmed-meshheading:14654082-Child,
pubmed-meshheading:14654082-Child, Preschool,
pubmed-meshheading:14654082-Chromosome Aberrations,
pubmed-meshheading:14654082-Chromosome Deletion,
pubmed-meshheading:14654082-Chromosomes, Human, Pair 5,
pubmed-meshheading:14654082-Chromosomes, Human, Pair 7,
pubmed-meshheading:14654082-Cytogenetic Analysis,
pubmed-meshheading:14654082-Disease Progression,
pubmed-meshheading:14654082-Female,
pubmed-meshheading:14654082-Humans,
pubmed-meshheading:14654082-In Situ Hybridization, Fluorescence,
pubmed-meshheading:14654082-Incidence,
pubmed-meshheading:14654082-Leukemia, Myeloid,
pubmed-meshheading:14654082-Male,
pubmed-meshheading:14654082-Middle Aged,
pubmed-meshheading:14654082-Monosomy,
pubmed-meshheading:14654082-Myelodysplastic Syndromes,
pubmed-meshheading:14654082-Prognosis
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pubmed:year |
2004
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pubmed:articleTitle |
Hidden chromosomal aberrations are rare in primary myelodysplastic syndromes with evolution to acute myeloid leukaemia and normal cytogenetics.
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pubmed:affiliation |
Institute of Human Genetics and Anthropology, Heinrich-Heine University, Universitätsstr. 1, 40225 Düsseldorf, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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