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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
1993-1-19
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pubmed:abstractText |
The pathogenesis of progressive spastic paraparesis [HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP)], a serious consequence of human T-cell leukemia virus type I (HTLV-I) infection, is unclear. T and B lymphocytes can be naturally infected by HTLV-I, but the susceptibility to HTLV-I infection of other cell types that could contribute to the pathogenesis of HAM/TSP has not been determined. We found that a human monocyte cell line (THP-1), primary human peripheral blood monocytes, and isolated microglial cells but not astrocytes or oligodendroglial cells derived from adult human brain were infected by HTLV-I in vitro. Infection with HTLV-I enhanced the secretion of interleukin 6 in human microglial cell-enriched cultures but did not stimulate the release of interleukin 1 from monocytes or microglial cells. Tumor necrosis factor alpha production was stimulated by HTLV-I infection of monocytes and microglial cells and could be enhanced by suboptimal amounts of lipopolysaccharide. Since both tumor necrosis factor alpha and interleukin 6 have been implicated in inflammatory demyelination and gliosis, our findings suggest that human microglial cells and monocytes infected with and activated by HTLV-I could play a role in the pathogenesis of HAM/TSP.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-1548752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-1548758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-1572977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-1646840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-1648577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-1671392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-1745362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-1826616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-1853937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-1908086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-1908877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-1967218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-1970111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2101630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2146511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2148832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2200125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2230595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2264889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2332735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2492759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2787512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2802532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2817828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2847164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2854202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2897399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2900211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2990037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-2992082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-3018755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-3030566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-3037548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-3073195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-3116087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-3167199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-3207295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-3349526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-3375080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-3919388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-6087161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-6095308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-6256763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-6316502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1465399-6979356
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11784-8
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1465399-Brain,
pubmed-meshheading:1465399-Cells, Cultured,
pubmed-meshheading:1465399-HTLV-I Infections,
pubmed-meshheading:1465399-Human T-lymphotropic virus 1,
pubmed-meshheading:1465399-Humans,
pubmed-meshheading:1465399-Interleukin-6,
pubmed-meshheading:1465399-Monocytes,
pubmed-meshheading:1465399-Neuroglia,
pubmed-meshheading:1465399-RNA, Messenger,
pubmed-meshheading:1465399-RNA, Viral,
pubmed-meshheading:1465399-Tumor Cells, Cultured,
pubmed-meshheading:1465399-Tumor Necrosis Factor-alpha
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pubmed:year |
1992
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pubmed:articleTitle |
Human T-cell leukemia virus type I infection of monocytes and microglial cells in primary human cultures.
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pubmed:affiliation |
Retrovirus Research Center, Department of Veterans Affairs Medical Center, Baltimore, MD 21218.
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pubmed:publicationType |
Journal Article
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