Linked Life Data

14652798

Source:http://linkedlifedata.com/resource/pubmed/id/14652798

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
37-38
pubmed:dateCreated
2003-12-3
pubmed:abstractText
The liver appears to be an organ favoring the induction of immune tolerance rather than immunity. Among the hepatic cell populations possibly involved in regulation of immune responses, liver sinusoidal endothelial cells (LSEC) are well suited to fulfill this role. LSEC are resident cells lining the hepatic sinusoidal wall and therefore are in intimate contact with leukocytes passing through the liver. They are equipped with numerous scavenger receptors rendering antigen-uptake in these cells extremely efficient. Antigen processing and MHC-restricted presentation of exogenous antigens for CD4 as well as CD8 T cells occurs equally with high efficiency. Importantly, CD4 and CD8 T cells that engaged in cognate interaction with LSEC have a tolerant phenotype. Thus LSEC contribute an important immune function to the liver: control of the immune response against circulating soluble antigens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1424-7860
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
501-6
pubmed:dateRevised
2011-2-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Control of immune responses by savenger liver endothelial cells.
pubmed:affiliation
Institute for Molecular Medicine and Experimental Immunology, University of Bonn, Germany. Percy.Knolle@ukb.uni-bonn.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't