| pubmed-article:14652008 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14652008 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:14652008 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:14652008 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:14652008 | lifeskim:mentions | umls-concept:C0968296 | lld:lifeskim |
| pubmed-article:14652008 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:14652008 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:14652008 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:14652008 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:14652008 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:14652008 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:14652008 | pubmed:dateCreated | 2003-12-3 | lld:pubmed |
| pubmed-article:14652008 | pubmed:abstractText | Two interleukin 13 receptors (IL-13Rs) have been identified as IL-13Ralpha1 and IL-13Ralpha2. IL-13Ralpha1 is composed of a heterodimer consisting of IL-13Ralpha1 and IL-4 receptor alpha (IL-4Ralpha) as a signaling subunit. In contrast, IL-13Ralpha2 is known as a decoy receptor for IL-13. In this study, we investigated the expression of IL-13Rs on human fibroblasts. IL-13Ralpha2 was significantly up-regulated after stimulation with tumor necrosis factor-alpha (TNF-alpha) and/or IL-4. In contrast, IL-13Ralpha1 was constitutively detectable and was not up-regulated. After the induction of IL-13alpha2 by IL-4, STAT6 phosphorylation through IL-13Ralpha1 by IL-13 was inhibited. We also detected large intracellular pools of IL-13Ralpha2 in fibroblasts quantitatively. Furthermore, mobilization of the IL-13Ralpha2 protein stores from the cytoplasm to the cell surface was prevented by an inhibitor of protein transport, brefeldin-A. These results indicate that TNF-alpha and IL-4 synergistically up-regulate the expression of IL-13Ralpha2 decoy receptor on human fibroblasts by inducing gene expression and mobilizing intracellular receptors, and thus may down-regulate the IL-13 signaling. | lld:pubmed |
| pubmed-article:14652008 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14652008 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14652008 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14652008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14652008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14652008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14652008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14652008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14652008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14652008 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14652008 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14652008 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14652008 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:14652008 | pubmed:author | pubmed-author:NakajimaToshi... | lld:pubmed |
| pubmed-article:14652008 | pubmed:author | pubmed-author:SaitoHirohisa... | lld:pubmed |
| pubmed-article:14652008 | pubmed:author | pubmed-author:MatsumotoKenj... | lld:pubmed |
| pubmed-article:14652008 | pubmed:author | pubmed-author:MoriyamaHiros... | lld:pubmed |
| pubmed-article:14652008 | pubmed:author | pubmed-author:YoshikawaMamo... | lld:pubmed |
| pubmed-article:14652008 | pubmed:author | pubmed-author:IidaMakotoM | lld:pubmed |
| pubmed-article:14652008 | pubmed:author | pubmed-author:OtoriNobuyosh... | lld:pubmed |
| pubmed-article:14652008 | pubmed:author | pubmed-author:TsukidateTosh... | lld:pubmed |
| pubmed-article:14652008 | pubmed:author | pubmed-author:HarunaShin-ic... | lld:pubmed |
| pubmed-article:14652008 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14652008 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:14652008 | pubmed:volume | 312 | lld:pubmed |
| pubmed-article:14652008 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14652008 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14652008 | pubmed:pagination | 1248-55 | lld:pubmed |
| pubmed-article:14652008 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:14652008 | pubmed:meshHeading | pubmed-meshheading:14652008... | lld:pubmed |
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| pubmed-article:14652008 | pubmed:meshHeading | pubmed-meshheading:14652008... | lld:pubmed |
| pubmed-article:14652008 | pubmed:meshHeading | pubmed-meshheading:14652008... | lld:pubmed |
| pubmed-article:14652008 | pubmed:meshHeading | pubmed-meshheading:14652008... | lld:pubmed |
| pubmed-article:14652008 | pubmed:meshHeading | pubmed-meshheading:14652008... | lld:pubmed |
| pubmed-article:14652008 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14652008 | pubmed:articleTitle | TNF-alpha and IL-4 regulate expression of IL-13 receptor alpha2 on human fibroblasts. | lld:pubmed |
| pubmed-article:14652008 | pubmed:affiliation | Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3-35-31 Taishidou, Setagaya-ku, 154-8567, Tokyo, Japan. | lld:pubmed |
| pubmed-article:14652008 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14652008 | pubmed:publicationType | Comparative Study | lld:pubmed |
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