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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-12-3
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pubmed:abstractText |
The Tal1 gene (also called Scl or TCL5) encodes a basic helix-loop-helix transcription factor required for hematopoiesis and vasculogenesis. Additionally, aberrant transcriptional activation of the Tal1 gene is a frequent event in human T cell acute lymphoblastic leukemia (T-ALL). T cell specific expression of TAL1 in mice induces aggressive T cell malignancies, demonstrating the oncogenic potential of TAL1. Yet, the underlying mechanisms of TAL1 induced tumorigenesis are poorly understood. By inhibiting E protein mediated transcription of the pTalpha gene, TAL1 can interfere with the T cell differentiation program. In addition, several studies suggest that TAL1 expression might also enhance proliferation rate. We report here that TAL1 can bind the E boxes in both the p16 and the pTalpha promoters, and functionally suppress the activity of both promoters. These results indicate that TAL1 can affect both T cell proliferation and differentiation. Moreover, we show that overexpression of TAL1 in hematopoietic progenitor cells promotes cell cycle division.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/TAL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/pre-T cell receptor alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
312
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1073-81
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:14651981-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:14651981-Cell Cycle,
pubmed-meshheading:14651981-Cell Line,
pubmed-meshheading:14651981-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:14651981-DNA-Binding Proteins,
pubmed-meshheading:14651981-Down-Regulation,
pubmed-meshheading:14651981-Gene Expression Regulation,
pubmed-meshheading:14651981-Genes, p16,
pubmed-meshheading:14651981-HeLa Cells,
pubmed-meshheading:14651981-Hematopoietic Stem Cells,
pubmed-meshheading:14651981-Humans,
pubmed-meshheading:14651981-Membrane Glycoproteins,
pubmed-meshheading:14651981-Proto-Oncogene Proteins,
pubmed-meshheading:14651981-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:14651981-Transcription Factors,
pubmed-meshheading:14651981-Transcriptional Activation
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pubmed:year |
2003
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pubmed:articleTitle |
The basic helix-loop-helix transcription factor TAL1/SCL inhibits the expression of the p16INK4A and pTalpha genes.
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pubmed:affiliation |
Department of Laboratory Medicine, Division of Molecular Medicine, Lund University, University Hospital MAS, SE-205 02, Malmö, Sweden.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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