Linked Life Data

14651786

Source:http://linkedlifedata.com/resource/pubmed/id/14651786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2003-12-3
pubmed:abstractText
Animal studies show that exposure to polychlorinated biphenyls (PCBs) or other persistent organochlorine compounds can disrupt thyroid hormone homeostasis. In some reports dietary exposures to PCBs have also been claimed to affect circulating levels of thyroid hormones and thyrotropin (TSH) in humans. The aim of the present study was to review available epidemiologic studies within this field. A total of 13 studies fulfilled the inclusion criteria for the review. The overall impression is a lack of consistency between studies of reported correlations, neither are there any obvious interstudy dose-response associations. Thus, it cannot presently be concluded that PCB exposure has been convincingly shown to affect thyroid hormone homeostasis in humans. On the other hand, available data do not exclude such associations. It is important to be aware of the intrinsic limitations of the cross-sectional epidemiologic studies used.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1050-7256
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1021-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Polychlorinated biphenyls and thyroid status in humans: a review.
pubmed:affiliation
Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden. lars.hagmar@ymed.lu.se
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't