Linked Life Data

14651451

Source:http://linkedlifedata.com/resource/pubmed/id/14651451

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-12-3
pubmed:abstractText
We report the first major genetic study of mild mental impairment. From a representative sample of 3886 twins (1314 monozygotic, 1296 dizygotic same-sex, and 1276 dizygotic opposite-sex), the lowest 5% were selected on a composite measure of verbal and nonverbal abilities assessed by parents when the twins were 2, 3, and 4 years of age. Twin concordances for mild mental impairment were 74% for monozygotic twins, 45% for same-sex, and 36% for opposite-sex dizygotic twins, indicating substantial genetic influence. Model-fitting analyses estimated group heritability as.49, which is significantly greater than heritability for the rest of the population in early childhood. These results suggest that mild mental impairment is a good target for neuroscience research on global brain function and dysfunction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0895-8017
pubmed:author
pubmed:issnType
Print
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
34-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Substantial genetic influence on mild mental impairment in early childhood.
pubmed:affiliation
Department of Psychology, University of Bielefeld, Bielefeld, Germany. fspin@uni-bielefeld.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Twin Study