Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6406
|
| pubmed:dateCreated |
1993-1-21
|
| pubmed:abstractText |
The proto-oncogene c-fos is the cellular homologue of v-fos originally isolated from murine osteosarcoma. Fos protein is a major component of the AP-1 transcription factor complex, which includes members of the jun family. Stable expression of c-fos in mice has been demonstrated in developing bones and teeth, haematopoietic cells, germ cells and in the central nervous system. It has been proposed that c-fos has an important role in signal transduction, cell proliferation and differentiation. We have previously demonstrated that overexpression of c-fos in transgenic and chimaeric mice specifically affects bone, cartilage and haematopoietic cell development. To understand better the function of c-fos in vivo, we used gene targeting in embryonic stem cells to generate cells and mice lacking c-fos. Here we report that heterozygous fos +/- mice appear normal, although females exhibit a distorted transmission frequency. All homozygous fos -/- mice are growth-retarded, develop osteopetrosis with deficiencies in bone remodelling and tooth eruption, and have altered haematopoiesis. These data define the c-Fos protein as an essential molecule for the development of specific cellular compartments.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0028-0836
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
360
|
| pubmed:geneSymbol |
c-fos
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
741-5
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1465144-Animals,
pubmed-meshheading:1465144-B-Lymphocytes,
pubmed-meshheading:1465144-Bone Development,
pubmed-meshheading:1465144-Bone and Bones,
pubmed-meshheading:1465144-Female,
pubmed-meshheading:1465144-Gene Deletion,
pubmed-meshheading:1465144-Genes, fos,
pubmed-meshheading:1465144-Hematopoiesis,
pubmed-meshheading:1465144-Heterozygote,
pubmed-meshheading:1465144-Homozygote,
pubmed-meshheading:1465144-Male,
pubmed-meshheading:1465144-Mice,
pubmed-meshheading:1465144-Mice, Inbred C57BL,
pubmed-meshheading:1465144-Mice, Transgenic,
pubmed-meshheading:1465144-Osteopetrosis,
pubmed-meshheading:1465144-Restriction Mapping,
pubmed-meshheading:1465144-Spleen,
pubmed-meshheading:1465144-T-Lymphocytes,
pubmed-meshheading:1465144-Thymus Gland,
pubmed-meshheading:1465144-Tooth Eruption
|
| pubmed:articleTitle |
Bone and haematopoietic defects in mice lacking c-fos.
|
| pubmed:affiliation |
Research Institute of Molecular Pathology (IMP), Vienna, Austria.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|