Linked Life Data

14650398

Source:http://linkedlifedata.com/resource/pubmed/id/14650398

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-12-1
pubmed:abstractText
The origin and development of pharmacogenetics are traced with emphasis on early hints by Garrod, Haldane, and later by RJ Williams. The field was delineated by Motulsky in 1957 and described as pharmacogenetics by Vogel in 1959. Kalow's monograph (1962) definitely established the discipline. Resemblance of identical twins in drug metabolism as compared with non identical twins (Vesell, 1970's) established the general importance of polygenic inheritance in disposal of many drugs. Ecogenetics was defined by Brewer in 1971 as dealing with genetic variation affecting the response to any environmental agents with emphasis on xenobiotics. More recent developments have broadened pharmacogenetic approaches to include novel genomic techniques with introduction of the term pharmacogenomics in the 1990's. Genetic and genomic approaches (toxicogenetics and toxicogenomics) are also being applied in the "environmental genome project". The interaction of genetic variation with dietary factors led to the field of Nutritional ecogenetics (Nutrigenomics) which relates the role of genetics to nutritional requirements and nutrition-mediated susceptibility to chronic disease. The total promise of pharmacogenomics is often overstated. The field is likely to have an impact on choice of drug therapy and avoidance of adverse events but is unlikely to lead to a revolution in therapeutics. Aspects of pharmacogenomic approaches and its applications including problems of premature commercialization are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
Q
pubmed:status
MEDLINE
pubmed:issn
0394-9001
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
HMD
pubmed:authorsComplete
Y
pubmed:pagination
683-705
pubmed:dateRevised
2005-2-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
From pharmacogenetics and ecogenetics to pharmacogenomics.
pubmed:affiliation
Department of Medicine and Genome Sciences, University of Washington, Seattle, USA.
pubmed:publicationType
Journal Article, Historical Article