Source:http://linkedlifedata.com/resource/pubmed/id/14648338
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2003-12-15
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pubmed:abstractText |
This study was conducted to evaluate the outcome of pediatric renal transplants at our center. A retrospective analysis was done on 39 pediatric transplants (age at transplant <18 years) done at our center over the last 10 years. The mean age at transplant was 15.6+/-1 years (10-17 years). They comprised 4.2% of all renal transplants done at our center (39/921) over the period. Girls comprised 17.5% of total recipients ( n=7). Two patients had a preemptive transplant. The underlying causes of end stage renal disease were chronic glomerulonephritis ( n=21), chronic interstitial nephritis ( n=17) and Alport syndrome [1]. All the 39 children were initiated on triple drug immunosuppression (cyclosporin A (CsA) azathioprine, prednisolone). All patients received grafts from living related donors. In the first month, three patients had graft loss (serum creatinine, SCr, >5 mg/dl). Of these, two patients died because of septicemia and one had acute cortical necrosis. There was evidence of infection in 16 patients (40%). Acute rejection was seen in 17 patients (45.8%). The 1-year patient and graft survival was 89% and at 3 years 70%. The actuarial graft survival at 5 years was 50%. Twelve children discontinued CsA after 1 year post-transplant and five of these had graft loss. Graft losses were significantly greater in patients who discontinued CsA as compared to those who continued CsA (5/12 vs 2/22). After a mean follow-up of 31.5+/-3.5 months, of the 37 patients, 10 had graft loss and chronic graft dysfunction was observed in another 9 patients. The rest of the 17 (48%) patients had a mean SCr of 1.2 mg/dl. The long-term outcome of pediatric renal transplants in our country remains suboptimal. CsA discontinuation due to financial constraints and/or non-compliance remain the most important reasons for this.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0931-041X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96-100
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14648338-Adolescent,
pubmed-meshheading:14648338-Azathioprine,
pubmed-meshheading:14648338-Child,
pubmed-meshheading:14648338-Cyclosporine,
pubmed-meshheading:14648338-Female,
pubmed-meshheading:14648338-Graft Rejection,
pubmed-meshheading:14648338-Humans,
pubmed-meshheading:14648338-Immunosuppressive Agents,
pubmed-meshheading:14648338-India,
pubmed-meshheading:14648338-Kidney Failure, Chronic,
pubmed-meshheading:14648338-Kidney Transplantation,
pubmed-meshheading:14648338-Male,
pubmed-meshheading:14648338-Prednisolone,
pubmed-meshheading:14648338-Retrospective Studies,
pubmed-meshheading:14648338-Treatment Outcome
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pubmed:year |
2004
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pubmed:articleTitle |
Outcome of pediatric renal transplants in a developing country.
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pubmed:affiliation |
Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. gulatis@mcmaster.ca
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pubmed:publicationType |
Journal Article,
Comparative Study
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