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pubmed-article:14646362pubmed:abstractTextIntegrins are adhesion molecules of fundamental importance to the recruitment of leucocytes in inflammation. The alpha4beta1 integrin (VLA-4) is a leucocyte ligand for endothelial vascular cell adhesion molecule-1 (VCAM-1), fibronectin and osteopontin. We addressed the role of VLA-4 in mediating progressive renal injury in vivo using a blocking monoclonal antibody (mAb) in a rat model of crescentic glomerulonephritis.lld:pubmed
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pubmed-article:14646362pubmed:copyrightInfoCopyright 2003 S. Karger AG, Basellld:pubmed
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pubmed-article:14646362pubmed:articleTitleBlocking VLA-4 prevents progression of experimental crescentic glomerulonephritis.lld:pubmed
pubmed-article:14646362pubmed:affiliationRenal Section, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK. s.khan@imperial.ac.uklld:pubmed
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