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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2003-12-3
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pubmed:abstractText |
Integrins are adhesion molecules of fundamental importance to the recruitment of leucocytes in inflammation. The alpha4beta1 integrin (VLA-4) is a leucocyte ligand for endothelial vascular cell adhesion molecule-1 (VCAM-1), fibronectin and osteopontin. We addressed the role of VLA-4 in mediating progressive renal injury in vivo using a blocking monoclonal antibody (mAb) in a rat model of crescentic glomerulonephritis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1660-2129
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 S. Karger AG, Basel
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pubmed:issnType |
Electronic
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e100-10
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pubmed:meshHeading |
pubmed-meshheading:14646362-Albuminuria,
pubmed-meshheading:14646362-Animals,
pubmed-meshheading:14646362-Anti-Glomerular Basement Membrane Disease,
pubmed-meshheading:14646362-Antibodies, Monoclonal,
pubmed-meshheading:14646362-Basement Membrane,
pubmed-meshheading:14646362-Cicatrix,
pubmed-meshheading:14646362-Creatinine,
pubmed-meshheading:14646362-Drug Administration Schedule,
pubmed-meshheading:14646362-Immune Sera,
pubmed-meshheading:14646362-Immunoglobulin G,
pubmed-meshheading:14646362-Integrin alpha4beta1,
pubmed-meshheading:14646362-Kidney Glomerulus,
pubmed-meshheading:14646362-Rabbits,
pubmed-meshheading:14646362-Rats,
pubmed-meshheading:14646362-Rats, Inbred WKY
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pubmed:year |
2003
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pubmed:articleTitle |
Blocking VLA-4 prevents progression of experimental crescentic glomerulonephritis.
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pubmed:affiliation |
Renal Section, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, UK. s.khan@imperial.ac.uk
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pubmed:publicationType |
Journal Article
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