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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017837,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0061200,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0227525,
umls-concept:C0443199,
umls-concept:C0796516,
umls-concept:C1711351,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2003-12-3
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pubmed:abstractText |
Geniposide, an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis, has the biological capabilities of detoxication, antioxidation, and anticarcinogenesis. In this study, the mechanism of geniposide affecting the GST (glutathione S-transferase) system was investigated. Primary cultured rat hepatocytes were treated with geniposide and examined for total GST activity and expression of GST subunits. The results showed that the geniposide-induced GST activity was dose and time dependent. Western blotting data demonstrated that geniposide induced increased protein levels of GSTM1 and GSTM2 (approximately 1.7- and 1.8-fold of control, respectively), but did not increase those of GSTA1. The corresponding transcripts levels were confirmed by RT-PCR. Using PD98059, the effect of geniposide was verified to be via the MEK pathway. The results suggest that geniposide possesses a potential for detoxication by inducing GST activity via increasing the transcription of GSTM1 and GSTM2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosides,
http://linkedlifedata.com/resource/pubmed/chemical/Iridoids,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/PD 98059,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrans,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/geniposide,
http://linkedlifedata.com/resource/pubmed/chemical/glutathione S-transferase M1,
http://linkedlifedata.com/resource/pubmed/chemical/glutathione S-transferase Mu 2
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0031-7012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2004 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15-22
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pubmed:dateRevised |
2007-5-12
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pubmed:meshHeading |
pubmed-meshheading:14646352-Animals,
pubmed-meshheading:14646352-Cells, Cultured,
pubmed-meshheading:14646352-Dose-Response Relationship, Drug,
pubmed-meshheading:14646352-Drugs, Chinese Herbal,
pubmed-meshheading:14646352-Enzyme Induction,
pubmed-meshheading:14646352-Flavonoids,
pubmed-meshheading:14646352-Fruit,
pubmed-meshheading:14646352-Glutathione Transferase,
pubmed-meshheading:14646352-Glycosides,
pubmed-meshheading:14646352-Hepatitis,
pubmed-meshheading:14646352-Hepatocytes,
pubmed-meshheading:14646352-Iridoids,
pubmed-meshheading:14646352-Isoenzymes,
pubmed-meshheading:14646352-Male,
pubmed-meshheading:14646352-Plant Extracts,
pubmed-meshheading:14646352-Pyrans,
pubmed-meshheading:14646352-RNA, Messenger,
pubmed-meshheading:14646352-Rats,
pubmed-meshheading:14646352-Rats, Sprague-Dawley,
pubmed-meshheading:14646352-Rubiaceae,
pubmed-meshheading:14646352-Time Factors
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pubmed:year |
2004
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pubmed:articleTitle |
Differential induction of the expression of GST subunits by geniposide in rat hepatocytes.
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pubmed:affiliation |
Division of Gastroenterology, Department of Internal Medicine, Armed Forces Taichung General Hospital, Taichung, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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