Source:http://linkedlifedata.com/resource/pubmed/id/14646292
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2003-12-3
|
| pubmed:abstractText |
Hospital waste incinerator workers are exposed to various pyrolysis products including polycyclic aromatic hydrocarbons (PAHs). We evaluated their exposure by assessing urinary 1-hydroxypyrene glucuronide (1-OHPG), as an internal dose of PAH exposure. The potential effect of genetic polymorphisms of GSTM1/T1 involved in PAH metabolisms was also investigated. Pre- and post-shift samples were collected from 28 hospital incinerator workers. Urinary 1-OHPG was assayed by synchronous fluorescence spectroscopy (SFS) after immunoaffinity purification with the monoclonal antibody 8E11. Genotypes of GSTM1/T1 were assessed by PCR-based methods. Information on smoking habits and use of personal protective equipment were collected by means of a self-administered questionnaire. The Mann-Whitney test was used to compare group means of these biomarkers. Urinary 1-OHPG levels were similar in pre- and post-shift urine samples. The arithmetic mean concentrations of urinary 1-OHPG were 0.16 +/- 0.04 micromol/mol creatinine pre-shift and 0.19 +/- 0.09 micromol/mol creatinine post-shift, but urinary 1-OHPG levels were significantly higher in individuals with the GSTM1 null genotype than with the GSTM1 present genotype (p=0.05, by Mann-Whitney test). Our results suggest that the urinary 1-OHPG levels in hospital waste incinerator workers may be modified by the GSTM1 genotype, but these findings remain to be confirmed in future studies involving larger sample sizes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-hydroxypyrene-glucuronide,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Adducts,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronates,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Polycyclic Hydrocarbons, Aromatic,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrenes,
http://linkedlifedata.com/resource/pubmed/chemical/glutathione S-transferase M1
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1341-9145
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
168-71
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:14646292-Adult,
pubmed-meshheading:14646292-DNA Adducts,
pubmed-meshheading:14646292-Genotype,
pubmed-meshheading:14646292-Glucuronates,
pubmed-meshheading:14646292-Glutathione Transferase,
pubmed-meshheading:14646292-Hospitals,
pubmed-meshheading:14646292-Humans,
pubmed-meshheading:14646292-Incineration,
pubmed-meshheading:14646292-Inhalation Exposure,
pubmed-meshheading:14646292-Korea,
pubmed-meshheading:14646292-Male,
pubmed-meshheading:14646292-Middle Aged,
pubmed-meshheading:14646292-Occupational Exposure,
pubmed-meshheading:14646292-Polycyclic Hydrocarbons, Aromatic,
pubmed-meshheading:14646292-Polymorphism, Genetic,
pubmed-meshheading:14646292-Protective Clothing,
pubmed-meshheading:14646292-Pyrenes,
pubmed-meshheading:14646292-Questionnaires,
pubmed-meshheading:14646292-Statistics, Nonparametric
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Urinary PAH metabolites influenced by genetic polymorphisms of GSTM1 in male hospital incinerator workers.
|
| pubmed:affiliation |
Department of Preventive Medicine, Seoul National University College of Medicine, Korea.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|