Linked Life Data

14645484

Source:http://linkedlifedata.com/resource/pubmed/id/14645484

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
34
pubmed:dateCreated
2003-12-3
pubmed:abstractText
In vivo tracking of hematogenous macrophages has been a major challenge because these cells are key players in nerve injury and repair. We visualized the spatiotemporal course of macrophage infiltration after acute peripheral nerve injury in living rats by using superparamagnetic iron oxide (SPIO) particles and magnetic resonance imaging (MRI). A signal loss on MR images indicating iron accumulation was present in degenerating sciatic nerves between days 1 and 8 after a crush lesion, ceased thereafter, and corresponded to the transient presence of iron-labeled ED1-positive macrophages in tissue sections. In contrast, no SPIO accumulation was seen after optic nerve crush, which revealed microglial activation but lacked macrophage infiltration. SPIO-enhanced MRI provides a new tool to selectively visualize active periods of macrophage transmigration into the nervous system, thus enabling dynamic views on a fundamental process in a multitude of nerve disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
26
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10892-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Caught in the act: in vivo mapping of macrophage infiltration in nerve injury by magnetic resonance imaging.
pubmed:affiliation
Department of Neuroradiology, University of Würzburg, D-97080 Würzburg, Germany. bendszus@neuroradiologie.uni-wuerzburg.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't