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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2003-12-3
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pubmed:abstractText |
T cell factor (TCF)-1 is a T-cell-specific transcription factor that is expressed at all stages of T cell development. Deletion of the TCF-1 gene leads to an early block in thymocyte maturation precluding the study of its role at late stages and during positive selection of T cells. In this report we show that beta-catenin, a central effector in the Wnt-TCF-1 signaling pathway, regulates late stages of T cell development. Specifically, transgenic expression of beta-catenin enhances generation of mature thymocytes. Interestingly, CD8-expressing mature thymocytes were affected to a greater extent than CD4-expressing cells. These data suggest that the Wnt-beta-catenin-TCF-1 signaling pathway plays a role during late stages of T cell development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Perforin,
http://linkedlifedata.com/resource/pubmed/chemical/Pore Forming Cytotoxic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0953-8178
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1485-94
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:14645157-Animals,
pubmed-meshheading:14645157-Animals, Newborn,
pubmed-meshheading:14645157-Antibodies, Monoclonal,
pubmed-meshheading:14645157-Antigens, CD,
pubmed-meshheading:14645157-Antigens, CD3,
pubmed-meshheading:14645157-Antigens, CD4,
pubmed-meshheading:14645157-Antigens, CD8,
pubmed-meshheading:14645157-Blotting, Western,
pubmed-meshheading:14645157-Bone Marrow Transplantation,
pubmed-meshheading:14645157-Cell Count,
pubmed-meshheading:14645157-Cell Death,
pubmed-meshheading:14645157-Cell Differentiation,
pubmed-meshheading:14645157-Cell Division,
pubmed-meshheading:14645157-Cytoskeletal Proteins,
pubmed-meshheading:14645157-Flow Cytometry,
pubmed-meshheading:14645157-Gene Expression,
pubmed-meshheading:14645157-Heterozygote,
pubmed-meshheading:14645157-Histocompatibility Antigens Class I,
pubmed-meshheading:14645157-Histocompatibility Antigens Class II,
pubmed-meshheading:14645157-Homozygote,
pubmed-meshheading:14645157-Humans,
pubmed-meshheading:14645157-Interleukin-2,
pubmed-meshheading:14645157-Lymphocyte Subsets,
pubmed-meshheading:14645157-Membrane Glycoproteins,
pubmed-meshheading:14645157-Mice,
pubmed-meshheading:14645157-Mice, Inbred C57BL,
pubmed-meshheading:14645157-Mice, Knockout,
pubmed-meshheading:14645157-Mice, Transgenic,
pubmed-meshheading:14645157-Mutation,
pubmed-meshheading:14645157-Perforin,
pubmed-meshheading:14645157-Phenotype,
pubmed-meshheading:14645157-Pore Forming Cytotoxic Proteins,
pubmed-meshheading:14645157-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:14645157-Signal Transduction,
pubmed-meshheading:14645157-T-Lymphocyte Subsets,
pubmed-meshheading:14645157-T-Lymphocytes,
pubmed-meshheading:14645157-Thymus Gland,
pubmed-meshheading:14645157-Trans-Activators,
pubmed-meshheading:14645157-beta 2-Microglobulin,
pubmed-meshheading:14645157-beta Catenin
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pubmed:year |
2003
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pubmed:articleTitle |
beta-Catenin expression enhances generation of mature thymocytes.
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pubmed:affiliation |
Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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