14644661

Source:http://linkedlifedata.com/resource/pubmed/id/14644661

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0002351, umls-concept:C0020857, umls-concept:C0021745, umls-concept:C0025926, umls-concept:C0026809, umls-concept:C0053800, umls-concept:C0591833, umls-concept:C1268930, umls-concept:C1280500, umls-concept:C1457887, umls-concept:C1513867, umls-concept:C1709059
pubmed:issue	16
pubmed:dateCreated	2003-12-3
pubmed:abstractText	To investigate the effects of the estrogen receptor-binding molecule bisphenol A (BPA) on murine immune function in vivo, we fed a low dose of 2.5 micro g BPA/kg body weight/day to both normal C57BL/6 and lupus-prone NZB X NZW F(1) (NZB/NZW) 5-week-old mice for 1 week. Analysis of concanavalin A (ConA)-stimulated splenic mononuclear cells by ELISA demonstrated that BPA-fed C57BL/6 males produced, on average, 40% less interferon-gamma (IFN-gamma; p < 0.01) and C57BL/6 females 28% less IFN-gamma (p < 0.05) compared with controls. Treated female NZB/NZW mice were monitored for lupus disease symptoms, defined as proteinuria (> 100 mg/dL albumin in urine for 2 consecutive weeks). Before the development of proteinuria, BPA-fed NZB/NZW mice produced significantly less ConA-stimulated IFN-gamma than did controls and displayed an average reduction of 50% in immunoglobulin G2a (IgG2a) antibody production from lipopolysaccharide (LPS)-stimulated splenocytes (p < 0.05). It is striking that 5-week-old female NZB/NZW mice fed a 7-day low-dose course of BPA developed proteinuria an average of 7 weeks later than did controls. Once proteinuria developed, splenocytes were stimulated with ConA for cytokine analysis. The BPA-fed mice showed a dramatic reduction of 64% in IFN-gamma production and a 32% reduction in ConA-stimulated interleukin-10 (p < 0.05). The long-lasting effects of BPA on IFN-gamma and IgG2a production likely contributed to the increased symptom-free period of the NZB/NZW mice.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/R15 AI50595-01
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0330411
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Estrogens, Non-Steroidal, http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G, http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma, http://linkedlifedata.com/resource/pubmed/chemical/Phenols, http://linkedlifedata.com/resource/pubmed/chemical/bisphenol A
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0091-6765
pubmed:author	pubmed-author:AndersonKatherineK, pubmed-author:SawaiCatherineC, pubmed-author:Walser-KuntzDebbyD
pubmed:issnType	Print
pubmed:volume	111
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1883-7
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:14644661-Animals, pubmed-meshheading:14644661-Cytokines, pubmed-meshheading:14644661-Disease Progression, pubmed-meshheading:14644661-Dose-Response Relationship, Drug, pubmed-meshheading:14644661-Estrogens, Non-Steroidal, pubmed-meshheading:14644661-Female, pubmed-meshheading:14644661-Immunoglobulin G, pubmed-meshheading:14644661-Interferon-gamma, pubmed-meshheading:14644661-Lupus Vulgaris, pubmed-meshheading:14644661-Lymphocyte Subsets, pubmed-meshheading:14644661-Mice, pubmed-meshheading:14644661-Mice, Inbred C57BL, pubmed-meshheading:14644661-Mice, Inbred NZB, pubmed-meshheading:14644661-Phenols, pubmed-meshheading:14644661-Spleen
pubmed:year	2003
pubmed:articleTitle	Effect of bisphenol A on murine immune function: modulation of interferon-gamma, IgG2a, and disease symptoms in NZB X NZW F1 mice.
pubmed:affiliation	Department of Biology, Carleton College, Northfield, Minnesota 55057, USA.

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