Linked Life Data

14644456

Source:http://linkedlifedata.com/resource/pubmed/id/14644456

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2003-12-3
pubmed:abstractText
Age-related deterioration of auditory temporal acuity has been identified as a contributing factor in presbycusis. In the present study, the effects of aging and stimulus level on gap encoding and gap recovery functions were investigated by measuring near-field auditory evoked potentials in the inferior colliculus of eight 3 month old and eight 24 month old CBA/CaJ mice, in response to gap stimuli embedded in broadband noise (40, 60, and 80 dB SPL). Gap encoding was assessed by measuring latencies and amplitudes of peak features of the near-field response, and also with a procedure that calculated the root mean square of the response within specific time windows. The chief differences in gap encoding between young and old mice were longer gap thresholds, slower recovery functions, and longer response peak latencies for old mice at 60, but not 80 dB SPL, although the latency of the earliest measured peak remained delayed for this condition in the old compared with the young mice. These results demonstrate that age-related changes in temporal acuity may interact with stimulus level, and suggest that adequate amplification may be critically important for maintaining temporal acuity with advancing age.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0378-5955
pubmed:author
pubmed:issnType
Print
pubmed:volume
186
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-29
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Impaired gap encoding in aged mouse inferior colliculus at moderate but not high stimulus levels.
pubmed:affiliation
Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA. pallen@cvs.rochester.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.