Linked Life Data

14644348

Source:http://linkedlifedata.com/resource/pubmed/id/14644348

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2003-12-3
pubmed:abstractText
Genotoxic effects have been assessed in the fish Oreochromis mossambicus treated separately and conjointly with 0.2% ethylmethane sulphonate (EMS) and 0.05% beta-carotene (BC) during five different time periods (6, 24, 48, 72 and 96 h) by analysis of endpoints such as chromosome aberrations, abnormal red blood cell nuclei, abnormal sperm morphology and protein contents (both qualitative and quantitative) of selected tissues, viz. muscle, heart, eye, brain, gill, liver, spleen and kidney. In addition, the relative efficacy of three doses of BC 0.02, 0.05 and 0.1%, in ameliorating genotoxic effects of 0.2% EMS was also tested after a treatment period of 48 h. EMS caused chromosomal aberrations, nuclear anomalies in red blood cells, abnormal sperm morphology and an apparent alteration of protein synthesis in various tissues. Some of these genotoxic effects of EMS appeared to be ameliorated by all three doses of BC, of which the 0.02% dose showed a marginally better efficacy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-5107
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
542
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Ameliorating effect of beta-carotene on ethylmethane sulphonate-induced genotoxicity in the fish Oreochromis mossambicus.
pubmed:affiliation
Department of Zoology, University of Kalyani, Kalyani, 741235, West Bengal, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't