Linked Life Data

14644198

Source:http://linkedlifedata.com/resource/pubmed/id/14644198

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-12-3
pubmed:abstractText
The transcription factor nuclear factor kappaB (NF-kappaB) is a pleiotropic protein complex that is activated from a sequestered, cytoplasmic form by pro-inflammatory extracellular signals and cellular stress. Several hundred cellular genes have been shown to be regulated by NF-kappaB, including cytokines, chemokines and adhesion molecules. Nearly eight years ago, a flurry of publications showed that loss or suppression of NF-kappaB results in an enhanced sensitivity to apoptosis. In the ensuing years, activation of NF-kappaB has become almost synonymous with enhanced cell survival, although more recent data suggests that this transcription factor plays a more complex role in the regulation of cell death.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0955-0674
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
732-7
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery.
pubmed:affiliation
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109-0602, USA.
pubmed:publicationType
Journal Article, Review