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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2003-12-3
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pubmed:abstractText |
CCR5 is expressed in neurons but its function in this cellular context is hitherto poorly understood. We have generated CCR5-expressing SH-SY5Y neuroblastoma cells. CCR5 ligands induced cell death in these cells, but not in control neuroblastoma cells or in CCR5-expressing fibroblasts. CCR5-dependent killing of neuroblastoma cells occurred through apoptosis, since it was accompanied by caspase-3 activation and could be prevented by a caspase-3 inhibitor. Finally, cell killing by activated microglia was more rapid and extensive in CCR5-expressing neuroblastoma cells than in control cells. In summary, CCR5 may act as a death receptor in cells of neuronal lineage and therefore be involved in inflammatory neurodegeneration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Casp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-39
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14644028-Animals,
pubmed-meshheading:14644028-Apoptosis,
pubmed-meshheading:14644028-Caspase 3,
pubmed-meshheading:14644028-Caspases,
pubmed-meshheading:14644028-Cell Culture Techniques,
pubmed-meshheading:14644028-Cell Death,
pubmed-meshheading:14644028-Cell Line, Tumor,
pubmed-meshheading:14644028-Chemokines, CC,
pubmed-meshheading:14644028-Coculture Techniques,
pubmed-meshheading:14644028-Enzyme Activation,
pubmed-meshheading:14644028-Genetic Vectors,
pubmed-meshheading:14644028-Humans,
pubmed-meshheading:14644028-Ligands,
pubmed-meshheading:14644028-Mice,
pubmed-meshheading:14644028-Microglia,
pubmed-meshheading:14644028-NIH 3T3 Cells,
pubmed-meshheading:14644028-Neuroblastoma,
pubmed-meshheading:14644028-Neurons,
pubmed-meshheading:14644028-Phagocytosis,
pubmed-meshheading:14644028-Receptors, CCR5,
pubmed-meshheading:14644028-Transfection
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pubmed:year |
2003
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pubmed:articleTitle |
Chemokine-induced cell death in CCR5-expressing neuroblastoma cells.
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pubmed:affiliation |
Biology of Ageing Laboratory, Department of Geriatrics, Geneva University Hospitals, 1225 Chêne-Bourg, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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