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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2003-12-3
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pubmed:abstractText |
A series of optically pure 1,3-dioxolane nucleoside mimics was synthesized by a synthetic route that allowed incorporation of a 5R-methyl substituent from commercially available starting materials. The pyrrolo[2,3-d]pyrimidine heterocycle was chosen as a substitute for the purine derivative. Coupling of the pyrrolo[2,3-d]pyrimidine and the dioxolane was performed under solid-liquid phase transfer conditions. The ability to inhibit HCV RNA replication was assessed in a cell based subgenomic replicon assay. None of the described compounds displayed significant anti-HCV activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4455-8
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pubmed:meshHeading |
pubmed-meshheading:14643345-Antiviral Agents,
pubmed-meshheading:14643345-Dioxolanes,
pubmed-meshheading:14643345-Hepacivirus,
pubmed-meshheading:14643345-Indicators and Reagents,
pubmed-meshheading:14643345-Molecular Conformation,
pubmed-meshheading:14643345-Molecular Structure,
pubmed-meshheading:14643345-RNA, Viral,
pubmed-meshheading:14643345-RNA Replicase,
pubmed-meshheading:14643345-Structure-Activity Relationship,
pubmed-meshheading:14643345-Virus Replication
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pubmed:year |
2003
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pubmed:articleTitle |
Synthesis and evaluation of optically pure dioxolanes as inhibitors of hepatitis C virus RNA replication.
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pubmed:affiliation |
Department of Medicinal Chemistry, Isis Pharmaceuticals, Carlsbad, CA 92008, USA.
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pubmed:publicationType |
Journal Article
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