Linked Life Data

14641514

Source:http://linkedlifedata.com/resource/pubmed/id/14641514

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-12-3
pubmed:abstractText
The aim of this study was to provide an incremental cost-effectiveness analysis comparing intravenous immunoglobulin (IVIg) and prednisolone treatment for chronic inflammatory demyelinating polyradiculoneuropathy. Patients were recruited to a double-blind randomized crossover trial from nine European centres and received either prednisolone or IVIg during the first 6-week treatment period on which the economic evaluation was based. A societal perspective was adopted in measuring service use and costs, although the costs of lost employment were not included. The main outcome measure in the economic evaluation was the number of quality adjusted life years (QALYs) gained, with change in a 11-point disability scale used to measure clinical outcomes. Service use and quality of life data were available for 25 patients. Baseline costs were controlled for using a bootstrapped multiple regression model. The cost difference between the two treatments was estimated to be euro 3754 over the 6-week period. Health-related quality of life, as measured by the EuroQol EQ-5D instrument, increased more in the IVIg group but the difference was not statistically significant. Using a net-benefit approach it was shown that the probability of IVIg being cost-effective in comparison with prednisolone was 0.5 or above (i.e. was more likely to be cost-effective than cost-ineffective) only if one QALY was valued at over euro 250 000. The cost-effectiveness of IVIg is greatly affected by the price of IVIg and the amount administered. The impact of later side-effects of prednisolone on long-term costs and quality of life are likely to reduce the cost per QALY of IVIg treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1351-5101
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
687-94
pubmed:dateRevised
2009-6-26
pubmed:meshHeading
pubmed-meshheading:14641514-Algorithms, pubmed-meshheading:14641514-Anti-Inflammatory Agents, pubmed-meshheading:14641514-Cost-Benefit Analysis, pubmed-meshheading:14641514-Disability Evaluation, pubmed-meshheading:14641514-Double-Blind Method, pubmed-meshheading:14641514-Europe, pubmed-meshheading:14641514-Female, pubmed-meshheading:14641514-Humans, pubmed-meshheading:14641514-Immunization, Passive, pubmed-meshheading:14641514-Immunoglobulins, Intravenous, pubmed-meshheading:14641514-Male, pubmed-meshheading:14641514-Middle Aged, pubmed-meshheading:14641514-Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, pubmed-meshheading:14641514-Prednisolone, pubmed-meshheading:14641514-Quality of Life, pubmed-meshheading:14641514-Quality-Adjusted Life Years, pubmed-meshheading:14641514-Treatment Outcome
pubmed:year
2003
pubmed:articleTitle
Cost-utility analysis of intravenous immunoglobulin and prednisolone for chronic inflammatory demyelinating polyradiculoneuropathy.
pubmed:affiliation
Centre for the Economics of Mental Health, Health Services Research Department, Institute of Psychiatry, King's College London, UK. p.mccrone@iop.kcl.ac.uk
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't