Linked Life Data

14641513

Source:http://linkedlifedata.com/resource/pubmed/id/14641513

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-12-3
pubmed:abstractText
Peripheral neuropathy has been widely reported in patients with monoclonal gammopathy (MG), more frequently immunoglobulin M (IgM) or IgG than IgA. Nevertheless, it remains unclear whether this association has clinical or pathogenic relevance. In order to clarify the possible role of IgG/IgA MG in neuropathy, we studied the clinical and electrophysiological features of 15 consecutive patients with polyneuropathy and IgG/IgA-MG, and compared them to those of 40 patients with polyneuropathy associated with IgM-MG, previously reported. Nine middle-aged patients (60%) had a chronic progressive or relapsing demyelinating polyneuropathy (DP) that was clinically and electrophysiologically indistinguishable from classic chronic inflammatory demyelinating polyneuropathy (CIDP) and frequently responded to immunosuppressive treatments, both characteristics supporting a dysimmune process. Six older patients (40%) had a chronic axonal distal polyneuropathy similar to the so-called chronic cryptogenic sensory polyneuropathy: there was no clear relationship with the MG in these patients and the response to immunosuppressive treatments was poor. Several features allowed us to distinguish between polyneuropathies associated with IgG/IgA-MG (IgG/IgA-PN) considered together and polyneuropathies associated with IgM-MG (IgM-PN). In the first group, the proportion of patients with a predominantly sensory clinical picture (27%) was less than that in the second group (75%), and there were fewer changes in nerve conduction studies. In addition, we found that the nine patients with DP associated with IgG/IgA-MG (IgG/IgA-DP) differed from the 31 with DP associated with IgM-MG (IgM-DP): clinical and electrophysiological studies clearly showed that the demyelinating pattern was more heterogeneous in IgG/IgA-DP than in IgM-DP. The spectrum of polyneuropathies associated with IgG/IgA-MG is heterogeneous, including DP, which is similar to classic CIDP, and axonal polyneuropathy, in which the pathogenic role of the MG remains elusive. In addition, IgG/IgA-DP differ from IgM-DP on clinical and electrophysiological grounds, suggesting probable different physiopathological mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1351-5101
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
677-85
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:14641513-Adrenal Cortex Hormones, pubmed-meshheading:14641513-Adult, pubmed-meshheading:14641513-Aged, pubmed-meshheading:14641513-Anti-Inflammatory Agents, pubmed-meshheading:14641513-Disease Progression, pubmed-meshheading:14641513-Electrophysiology, pubmed-meshheading:14641513-Female, pubmed-meshheading:14641513-Humans, pubmed-meshheading:14641513-Immunoglobulin A, pubmed-meshheading:14641513-Immunoglobulin G, pubmed-meshheading:14641513-Immunoglobulin M, pubmed-meshheading:14641513-Male, pubmed-meshheading:14641513-Middle Aged, pubmed-meshheading:14641513-Movement Disorders, pubmed-meshheading:14641513-Neural Conduction, pubmed-meshheading:14641513-Neuropsychological Tests, pubmed-meshheading:14641513-Paraproteinemias, pubmed-meshheading:14641513-Polyneuropathies, pubmed-meshheading:14641513-Retrospective Studies, pubmed-meshheading:14641513-Treatment Outcome
pubmed:year
2003
pubmed:articleTitle
Polyneuropathy associated with IgG/IgA monoclonal gammopathy: a clinical and electrophysiological study of 15 cases.
pubmed:affiliation
Service de Neurologie, CHU Dupuytren, Limoges, France.
pubmed:publicationType
Journal Article, Comparative Study