|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0025663,
umls-concept:C0050587,
umls-concept:C0080194,
umls-concept:C0205314,
umls-concept:C0220781,
umls-concept:C0243071,
umls-concept:C0443288,
umls-concept:C0456387,
umls-concept:C0678594,
umls-concept:C0679622,
umls-concept:C1527178,
umls-concept:C1705938,
umls-concept:C1883254,
umls-concept:C2916808
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|
pubmed:issue |
25
|
|
pubmed:dateCreated |
2003-12-3
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|
pubmed:abstractText |
A series of conformationally restricted analogues of milnacipran, a weak NMDA receptor antagonist, were designed by a method based on allylic strain. The conformational analysis study showed that the allylic-strain-based conformational restriction indeed occurred and that the affinity for the NMDA receptor was efficiently improved by the conformational restriction.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
Dec
|
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pubmed:issn |
0022-2623
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
46
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
|
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pubmed:pagination |
5326-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14640541-Acrylamides,
pubmed-meshheading:14640541-Allyl Compounds,
pubmed-meshheading:14640541-Animals,
pubmed-meshheading:14640541-Cerebral Cortex,
pubmed-meshheading:14640541-Crystallography, X-Ray,
pubmed-meshheading:14640541-Models, Molecular,
pubmed-meshheading:14640541-Molecular Conformation,
pubmed-meshheading:14640541-Radioligand Assay,
pubmed-meshheading:14640541-Rats,
pubmed-meshheading:14640541-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:14640541-Stereoisomerism,
pubmed-meshheading:14640541-Structure-Activity Relationship
|
|
pubmed:year |
2003
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|
pubmed:articleTitle |
A method for designing conformationally restricted analogues based on allylic strain: synthesis of a novel class of noncompetitive NMDA receptor antagonists having the acrylamide structure.
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pubmed:affiliation |
Institute for Life Science Research, Asahi Kasei Co, Ltd, Ohito-cho, Shizuoka 410-2321, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
