Source:http://linkedlifedata.com/resource/pubmed/id/14639615
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2003-11-25
|
| pubmed:abstractText |
The lignan enterolactone produced by the intestinal microflora from dietary precursors has been hypothesized to protect against hormone-dependent cancers. We conducted a nested case-control study to examine the relationship between serum enterolactone concentration and risk of breast cancer. Enterolactone concentrations were measured by time-resolved fluoroimmunoassay in serum collected at 4 independent cross-sectional population surveys from 206 women with breast cancer diagnosed during follow-up (mean 8.0 years) and from 215 controls frequency-matched to cases by study cohort, 5-year age group and study area. Mean serum enterolactone concentration (nmol/l) did not significantly differ between case and control subjects [25.2 (SD 22.2) vs. 24.0 (SD 21.3), respectively]. Odds ratios for breast cancer risk estimated by conditional logistic regression for increasing concentration of enterolactone in quartiles were 1.00 (referent), 1.67 (95% CI 0.95-2.95), 1.71 (95% CI 0.96-3.06) and 1.30 (95% CI 0.73-2.31), and p for trend was 0.48. Our findings do not support the hypothesis that high serum enterolactone concentration is associated with reduced risk of breast cancer.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0020-7136
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2003 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
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| pubmed:day |
10
|
| pubmed:volume |
108
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
277-80
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| pubmed:dateRevised |
2007-7-24
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| pubmed:meshHeading |
pubmed-meshheading:14639615-4-Butyrolactone,
pubmed-meshheading:14639615-Adult,
pubmed-meshheading:14639615-Aged,
pubmed-meshheading:14639615-Breast Neoplasms,
pubmed-meshheading:14639615-Case-Control Studies,
pubmed-meshheading:14639615-Cross-Sectional Studies,
pubmed-meshheading:14639615-Estrogens,
pubmed-meshheading:14639615-Female,
pubmed-meshheading:14639615-Finland,
pubmed-meshheading:14639615-Fluoroimmunoassay,
pubmed-meshheading:14639615-Humans,
pubmed-meshheading:14639615-Lignans,
pubmed-meshheading:14639615-Middle Aged,
pubmed-meshheading:14639615-Odds Ratio,
pubmed-meshheading:14639615-Postmenopause,
pubmed-meshheading:14639615-Premenopause,
pubmed-meshheading:14639615-Prospective Studies,
pubmed-meshheading:14639615-Risk Factors
|
| pubmed:year |
2004
|
| pubmed:articleTitle |
Serum enterolactone concentration is not associated with breast cancer risk in a nested case-control study.
|
| pubmed:affiliation |
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland. annamari.kilkkinen@ktl.fi
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|