Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2003-12-5
pubmed:abstractText
Although elevated levels of IgE in asthmatic patients are strongly associated with lung infiltration by activated T helper (Th) 2 cells, the physiological role of immunoglobulin E (IgE) in the airway remains largely undefined. Lymphotoxin-deficient alpha (LTalpha-/-) mice exhibit increased airway inflammation, paradoxically accompanied by diminished levels of IgE and reduced airway hyperresponsiveness in response to both environmental and induced antigen challenge. The severe lung inflammation in LTalpha-/- mice is Th1 in nature and can be alleviated by IgE reconstitution. Conversely, depletion of IgE in wild-type mice recapitulates the lung pathologies of LTalpha-/- mice. Therefore, this work has revealed that lymphotoxin is essential for IgE production, and a physiological role of IgE in the airway may consist of maintaining the balance of Th1 and Th2 responses to prevent aberrant inflammation.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-10358764, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-10525040, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-10607813, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-11112855, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-11292025, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-11420048, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-11420049, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-11489981, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-11518731, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-11786643, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-11818486, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-11830666, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-11964470, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-12145657, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-12183167, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-12438442, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-1530827, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-1717839, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-1891008, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-2911321, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-7636227, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-7666875, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-8171322, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-8666888, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-8977202, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-9005985, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-9037055, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-9256477, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-9697836, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-9916129, http://linkedlifedata.com/resource/pubmed/commentcorrection/14638845-9973518
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
198
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1643-52
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammation.
pubmed:affiliation
Department of Pathology, The University of Chicago, Chicago, IL 60637, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.