Linked Life Data

14638326

Source:http://linkedlifedata.com/resource/pubmed/id/14638326

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-11-25
pubmed:abstractText
Human centromeric regions are enriched for segmental duplications, which elsewhere in the genome precipitate both genetic disease and gene formation. Molecular cytogenetic analyses of primate chromosomes have established that centromeres frequently move without altering the surrounding gene order. Recently, the positions of two ancestral centromeres have been mapped to regions of the human genome that are both rich in segmental duplications and are associated with duplication-based clinical phenotypes. This suggests a model for the evolution of euchromatic segmental duplication families involving the localised elevation of recombination rates within the duplication-rich heterochromatin of recently inactivated centromeres, and raises the possibility that the distribution of duplication/deletion syndromes within our genome has been heavily influenced by such events. The relaxation of the heterochromatin environment that must accompany centromere inactivation would also increase the transcriptional activity within previously pericentromeric DNA, increasing the likelihood of chimaeric gene creation through pericentromeric-directed duplication events.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0959-437X
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
629-35
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Duplicate, decouple, disperse: the evolutionary transience of human centromeric regions.
pubmed:affiliation
The Institute Of Human Genetics, The International Centre For Life, University Of Newcastle Upon Tyne, Central Parkway, Newcastle Upon Tyne NE1 3BZ, UK. m.s.jackson@ncl.ac.uk
pubmed:publicationType
Journal Article, Review