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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2003-11-25
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pubmed:abstractText |
The molecular basis of drug resistance in epilepsy is being explored. Two proteins associated with drug resistance in cancer, P-glycoprotein and multidrug resistance-associated protein 1, are upregulated in human epileptogenic pathologies. Other proteins associated with resistance in cancer include major vault protein (MVP) and breast cancer resistance protein (BCRP). We hypothesized that these proteins would also be upregulated in human epileptogenic pathologies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0013-9580
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1388-96
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14636345-ATP-Binding Cassette Transporters,
pubmed-meshheading:14636345-Anticonvulsants,
pubmed-meshheading:14636345-Brain Neoplasms,
pubmed-meshheading:14636345-Capillaries,
pubmed-meshheading:14636345-Cerebral Cortex,
pubmed-meshheading:14636345-Drug Resistance, Multiple,
pubmed-meshheading:14636345-Endothelium, Vascular,
pubmed-meshheading:14636345-Epilepsy,
pubmed-meshheading:14636345-Hippocampus,
pubmed-meshheading:14636345-Humans,
pubmed-meshheading:14636345-Immunoenzyme Techniques,
pubmed-meshheading:14636345-Neoplasm Proteins,
pubmed-meshheading:14636345-Neoplasms, Neuroepithelial,
pubmed-meshheading:14636345-Neurons,
pubmed-meshheading:14636345-Phenotype,
pubmed-meshheading:14636345-Reference Values,
pubmed-meshheading:14636345-Sclerosis,
pubmed-meshheading:14636345-Up-Regulation,
pubmed-meshheading:14636345-Vault Ribonucleoprotein Particles
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pubmed:year |
2003
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pubmed:articleTitle |
Major vault protein, a marker of drug resistance, is upregulated in refractory epilepsy.
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pubmed:affiliation |
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, England. sisodiya@ion.ucl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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