Linked Life Data

14635950

Source:http://linkedlifedata.com/resource/pubmed/id/14635950

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2003-11-25
pubmed:abstractText
Animals adjust the time of year that they reproduce through their ability to perceive and respond to critical aspects of their environment, such as photoperiod, nutrition or the socio-sexual milieu, and their genotype determines the degree of response to each stimulus. Ultimately, information from environmental cues filters through to the GnRH neurones in the brain which are the primary regulator of fertility. Each of these cues has been studied in isolation and the mechanisms by which they affect GnRH secretion are now better, if not fully, understood. In the field, the brain centres that control GnRH must integrate information from all cues at any given time before 'formulating a reproductive decision'. In this review, the effect of this integration is illustrated by showing how the acute GnRH response to a nutritional signal can be modulated by genotype, photoperiod and social cues, to the point of being completely blocked under some circumstances. Candidate pathways that may mediate these modulatory effects at both the whole body and brain have been proposed, although none of these pathways are confirmed and some have not yet been studied. As a guide for further research, we propose a working model that integrates the inputs and explains the interactions between them.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1477-0415
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
387-402
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Fertility in male sheep: modulators of the acute effects of nutrition on the reproductive axis of male sheep.
pubmed:affiliation
School of Animal Biology, Faculty of Natural and Agricultural Sciences, University of Western Australia, Crawley 6009, Australia. dblache@agric.uwa.edu.au
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't