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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2003-11-24
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pubmed:abstractText |
Alcohol abuse may involve an altered neuroendocrine response that mediates lymphocyte-derived proopiomelanocortin (POMC) production and inflammation. We investigated POMC messenger RNA (mRNA) expression in human lymphocytes ex vivo and their relation to plasma ACTH and immunoreactive beta-endorphin (IR-beta-EP) after intravenous injection of human corticotropin releasing factor (hCRF) in chronic alcoholics (n = 12) and nonalcoholics (n = 12) before surgery. Lipopolysaccharide-stimulated interleukin (IL)-1 receptor antagonist (IL-1 Ra) as a marker for chronic inflammation was determined.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0145-6008
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1693-700
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14634483-Adult,
pubmed-meshheading:14634483-Aged,
pubmed-meshheading:14634483-Alcoholism,
pubmed-meshheading:14634483-Corticotropin-Releasing Hormone,
pubmed-meshheading:14634483-Female,
pubmed-meshheading:14634483-Humans,
pubmed-meshheading:14634483-Lymphocytes,
pubmed-meshheading:14634483-Male,
pubmed-meshheading:14634483-Middle Aged,
pubmed-meshheading:14634483-Pro-Opiomelanocortin,
pubmed-meshheading:14634483-RNA, Messenger,
pubmed-meshheading:14634483-Statistics, Nonparametric
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pubmed:year |
2003
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|
pubmed:articleTitle |
Decreased proopiomelanocortin mRNA in lymphocytes of chronic alcoholics after intravenous human corticotropin releasing factor injection.
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pubmed:affiliation |
Department of Anesthesiology and Intensive Care, University Hospital Charité, Humboldt-University of Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
