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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2003-11-24
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pubmed:abstractText |
Glatiramer acetate (GA), a mixture of synthetic polypeptides, has beneficial effects on the clinical course and the MRI-defined disease activity of patients with multiple sclerosis (MS). In MS, evidence has been provided that the apoptosis of disease-relevant T cells is dysregulated. In this study, we investigated the effect of GA on T cell apoptosis, T cell activation, and cytokine profile of lymphocytes derived from 19 relapsing-remitting MS patients during the first year of GA therapy. Analysis of blood samples obtained every 6 weeks showed an increase in apoptotic T helper cells after 30 weeks of therapy. This effect remained until the end of the study and was accompanied by an increase in activated T cells and interleukin-4-producing lymphocytes. Thus, in addition to the established effect of GA on the cytokine network, GA-mediated immunomodulation might involve the apoptotic elimination of T helper cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD69 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/copolymer 1
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pubmed:status |
MEDLINE
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pubmed:issn |
0014-3022
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2003 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
200-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:14634263-Adult,
pubmed-meshheading:14634263-Antigens, CD,
pubmed-meshheading:14634263-Antigens, CD3,
pubmed-meshheading:14634263-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:14634263-Apoptosis,
pubmed-meshheading:14634263-CD4-Positive T-Lymphocytes,
pubmed-meshheading:14634263-CD8-Positive T-Lymphocytes,
pubmed-meshheading:14634263-Female,
pubmed-meshheading:14634263-Flow Cytometry,
pubmed-meshheading:14634263-Humans,
pubmed-meshheading:14634263-Immunosuppressive Agents,
pubmed-meshheading:14634263-Interferon-gamma,
pubmed-meshheading:14634263-Interleukin-4,
pubmed-meshheading:14634263-Lectins, C-Type,
pubmed-meshheading:14634263-Male,
pubmed-meshheading:14634263-Multiple Sclerosis,
pubmed-meshheading:14634263-Peptides,
pubmed-meshheading:14634263-Time Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Induction of apoptosis of CD4+ T cells by immunomodulatory therapy of multiple sclerosis with glatiramer acetate.
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pubmed:affiliation |
Department of Neurology, Zentrum für klinische Forschung, Neuroimmunology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany. maike.rieks@ruhr-uni-bochum.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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