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| pubmed-article:14634095 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:14634095 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:14634095 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:14634095 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:14634095 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:14634095 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:14634095 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:14634095 | lifeskim:mentions | umls-concept:C1326230 | lld:lifeskim |
| pubmed-article:14634095 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:14634095 | lifeskim:mentions | umls-concept:C2698594 | lld:lifeskim |
| pubmed-article:14634095 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:14634095 | pubmed:dateCreated | 2003-11-24 | lld:pubmed |
| pubmed-article:14634095 | pubmed:abstractText | Using transgenic mice that express a constitutively active version of STAT5b, we demonstrate that STAT5 plays a key role in governing B cell development and T cell homeostasis. STAT5 activation leads to a 10-fold increase in pro-B, but not pro-T, cells. Conversely, STAT5 signaling promotes the expansion of mature alphabeta T cells (6-fold increase) and gammadelta and NK T cells (3- to 4-fold increase), but not of mature B cells. In addition, STAT5 activation has dramatically divergent effects on CD8(+) vs CD4(+) T cells, leading to the selective expansion of CD8(+) memory-like T cells and CD4(+)CD25(+) regulatory T cells. These results establish that activation of STAT5 is the primary mechanism underlying both IL-7/IL-15-dependent homeostatic proliferation of naive and memory CD8(+) T cells and IL-2-dependent development of CD4(+)CD25(+) regulatory T cells. | lld:pubmed |
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| pubmed-article:14634095 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14634095 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:14634095 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14634095 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:14634095 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:14634095 | pubmed:author | pubmed-author:BrennanPaulP | lld:pubmed |
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| pubmed-article:14634095 | pubmed:author | pubmed-author:PrlicMartinM | lld:pubmed |
| pubmed-article:14634095 | pubmed:author | pubmed-author:JamesonStephe... | lld:pubmed |
| pubmed-article:14634095 | pubmed:author | pubmed-author:FarrarMichael... | lld:pubmed |
| pubmed-article:14634095 | pubmed:author | pubmed-author:BurchillMatth... | lld:pubmed |
| pubmed-article:14634095 | pubmed:author | pubmed-author:GoetzChristin... | lld:pubmed |
| pubmed-article:14634095 | pubmed:author | pubmed-author:O'NeilJennife... | lld:pubmed |
| pubmed-article:14634095 | pubmed:author | pubmed-author:HarmonIan RIR | lld:pubmed |
| pubmed-article:14634095 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14634095 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:14634095 | pubmed:volume | 171 | lld:pubmed |
| pubmed-article:14634095 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14634095 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14634095 | pubmed:pagination | 5853-64 | lld:pubmed |
| pubmed-article:14634095 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
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| pubmed-article:14634095 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14634095 | pubmed:articleTitle | Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. | lld:pubmed |
| pubmed-article:14634095 | pubmed:affiliation | Center for Immunology, Cancer Center, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA. | lld:pubmed |
| pubmed-article:14634095 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14634095 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14634095 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14634095 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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