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rdf:type |
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lifeskim:mentions |
umls-concept:C0025260,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C1280500,
umls-concept:C1326230,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1335875,
umls-concept:C1413244,
umls-concept:C1527148,
umls-concept:C1705050,
umls-concept:C1706438,
umls-concept:C1879547,
umls-concept:C2698594,
umls-concept:C2698600
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pubmed:issue |
11
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pubmed:dateCreated |
2003-11-24
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pubmed:abstractText |
Using transgenic mice that express a constitutively active version of STAT5b, we demonstrate that STAT5 plays a key role in governing B cell development and T cell homeostasis. STAT5 activation leads to a 10-fold increase in pro-B, but not pro-T, cells. Conversely, STAT5 signaling promotes the expansion of mature alphabeta T cells (6-fold increase) and gammadelta and NK T cells (3- to 4-fold increase), but not of mature B cells. In addition, STAT5 activation has dramatically divergent effects on CD8(+) vs CD4(+) T cells, leading to the selective expansion of CD8(+) memory-like T cells and CD4(+)CD25(+) regulatory T cells. These results establish that activation of STAT5 is the primary mechanism underlying both IL-7/IL-15-dependent homeostatic proliferation of naive and memory CD8(+) T cells and IL-2-dependent development of CD4(+)CD25(+) regulatory T cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Milk Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/STAT5 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat5b protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5853-64
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:14634095-Animals,
pubmed-meshheading:14634095-B-Lymphocyte Subsets,
pubmed-meshheading:14634095-CD4-Positive T-Lymphocytes,
pubmed-meshheading:14634095-CD8-Positive T-Lymphocytes,
pubmed-meshheading:14634095-Cell Differentiation,
pubmed-meshheading:14634095-Cell Division,
pubmed-meshheading:14634095-Crosses, Genetic,
pubmed-meshheading:14634095-DNA-Binding Proteins,
pubmed-meshheading:14634095-Homeostasis,
pubmed-meshheading:14634095-Immunologic Memory,
pubmed-meshheading:14634095-Killer Cells, Natural,
pubmed-meshheading:14634095-Mice,
pubmed-meshheading:14634095-Mice, Transgenic,
pubmed-meshheading:14634095-Milk Proteins,
pubmed-meshheading:14634095-Receptors, Antigen, T-Cell,
pubmed-meshheading:14634095-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:14634095-Receptors, Interleukin-2,
pubmed-meshheading:14634095-STAT5 Transcription Factor,
pubmed-meshheading:14634095-Signal Transduction,
pubmed-meshheading:14634095-T-Lymphocyte Subsets,
pubmed-meshheading:14634095-T-Lymphocytes, Regulatory,
pubmed-meshheading:14634095-Trans-Activators,
pubmed-meshheading:14634095-Up-Regulation
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pubmed:year |
2003
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pubmed:articleTitle |
Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells.
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pubmed:affiliation |
Center for Immunology, Cancer Center, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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