Source:http://linkedlifedata.com/resource/pubmed/id/14633675
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
22
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| pubmed:dateCreated |
2003-11-24
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| pubmed:abstractText |
Recent studies showed that SV40 is detected in >40% of non-Hodgkin's lymphoma (NHL) in United States, suggesting SV40-contaminated poliovaccines widely used during the period 1955-1963 to be a major source of SV40 in NHL. We examined the presence of SV40 sequences in 122 cases with NHL and 3 with Hodgkin's lymphoma from Japan. The detection rate of SV40 sequences in diffuse large B-cell lymphoma (19%) was higher than that in peripheral blood cells of normal healthy volunteers in Japan (4.7%; P < 0.05) reported previously as controls for comparison with the study results from cancer patients, suggesting a role for SV40 in the development of diffuse large B-cell lymphoma. In contrast, the frequency of SV40 sequences in NHL cases born between 1951 and 1963 (12%), during which SV40-contaminated poliovaccines might have been inoculated, is not significantly different from that in cases born before 1950 (11%) or after 1964 (15%). SV40 is a new candidate etiologic factor for malignant lymphoma not only in the United States but also in Japan.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0008-5472
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
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| pubmed:volume |
63
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
7606-8
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:14633675-Adolescent,
pubmed-meshheading:14633675-Adult,
pubmed-meshheading:14633675-Aged,
pubmed-meshheading:14633675-Aged, 80 and over,
pubmed-meshheading:14633675-Antigens, Polyomavirus Transforming,
pubmed-meshheading:14633675-Child,
pubmed-meshheading:14633675-Child, Preschool,
pubmed-meshheading:14633675-Female,
pubmed-meshheading:14633675-Humans,
pubmed-meshheading:14633675-In Situ Hybridization,
pubmed-meshheading:14633675-Infant,
pubmed-meshheading:14633675-Japan,
pubmed-meshheading:14633675-Lymphoma, B-Cell,
pubmed-meshheading:14633675-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:14633675-Lymphoma, Non-Hodgkin,
pubmed-meshheading:14633675-Lymphoma, T-Cell,
pubmed-meshheading:14633675-Male,
pubmed-meshheading:14633675-Middle Aged,
pubmed-meshheading:14633675-Polymerase Chain Reaction,
pubmed-meshheading:14633675-Simian virus 40
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| pubmed:year |
2003
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| pubmed:articleTitle |
Simian virus 40 sequences in malignant lymphomas in Japan.
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| pubmed:affiliation |
Department of Pathology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
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| pubmed:publicationType |
Journal Article
|