Linked Life Data

14632194

Source:http://linkedlifedata.com/resource/pubmed/id/14632194

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pubmed-article:14632194pubmed:abstractTextPreviously, we reported the identification of autoantibodies against the melanin-concentrating hormone receptor 1 in patients with vitiligo. In this study, the B cell epitopes on melanin-concentrating hormone receptor 1 that are recognized by these autoantibodies have been identified. Deletion derivatives of melanin-concentrating hormone receptor 1 complementary DNA were constructed and then translated in vitro with the concomitant incorporation of [35S]-methionine into the protein products. The [35S]-labeled melanin-concentrating hormone receptor 1 derivatives were subsequently used in radio-binding assays to investigate the reactivity of sera from nine vitiligo patients that were known to contain antibodies to the receptor. Analysis of the results obtained in the radio-binding assays suggested the existence of multiple antibody binding sites on melanin-concentrating hormone receptor 1, including regions between amino acids 1 to 138 and 139 to 298. Several patients exhibited autoantibodies to more than one melanin-concentrating hormone receptor 1 epitope indicating a heterogeneous humoral response to the receptor. Computer prediction of the potential B cell epitopes on melanin-concentrating hormone receptor 1 revealed that the epitope domains identified overlapped, at least in part, with regions predicted to be highly antigenic.lld:pubmed
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pubmed-article:14632194pubmed:authorpubmed-author:HerdLaura MLMlld:pubmed
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pubmed-article:14632194pubmed:volume121lld:pubmed
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pubmed-article:14632194pubmed:pagination765-70lld:pubmed
pubmed-article:14632194pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:14632194pubmed:year2003lld:pubmed
pubmed-article:14632194pubmed:articleTitleAutoantibodies in vitiligo patients recognize multiple domains of the melanin-concentrating hormone receptor.lld:pubmed
pubmed-article:14632194pubmed:affiliationDivision of Clinical Sciences (North), University of Sheffield, Sheffield, UK.lld:pubmed
pubmed-article:14632194pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:14632194pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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