Linked Life Data

14630701

Source:http://linkedlifedata.com/resource/pubmed/id/14630701

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:14630701rdf:typepubmed:Citationlld:pubmed
pubmed-article:14630701lifeskim:mentionsumls-concept:C0597032lld:lifeskim
pubmed-article:14630701lifeskim:mentionsumls-concept:C0115305lld:lifeskim
pubmed-article:14630701lifeskim:mentionsumls-concept:C0431085lld:lifeskim
pubmed-article:14630701lifeskim:mentionsumls-concept:C0007577lld:lifeskim
pubmed-article:14630701lifeskim:mentionsumls-concept:C0024027lld:lifeskim
pubmed-article:14630701lifeskim:mentionsumls-concept:C1456820lld:lifeskim
pubmed-article:14630701lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:14630701lifeskim:mentionsumls-concept:C0599946lld:lifeskim
pubmed-article:14630701lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:14630701lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:14630701pubmed:issue1lld:pubmed
pubmed-article:14630701pubmed:dateCreated2004-1-13lld:pubmed
pubmed-article:14630701pubmed:abstractTextE-selectin mediated cell-cell adhesion plays an important role in inflammatory processes and extravasation of tumor cells. Tumor necrosis factor-alpha (TNF-alpha) induces E-selectin gene and protein expression in primary human endothelial cells (HUVEC) and in an endothelial cell line (EA.hy-926). As shown by ELISA and FACS analyses, HMG-CoA reductase inhibitors (e.g., lovastatin) impair the TNF-alpha stimulated increase in E-selectin protein expression. Similar results were obtained for E-selectin mRNA expression and promoter activity, indicating that the effect of lovastatin is based on inhibition of gene expression. The effective inhibitory concentration of lovastatin was in a physiologically relevant range (IC50<0.1 microM). Lovastatin-mediated block of TNF-alpha induced E-selectin expression is due to inhibition of protein geranylgeranylation rather than farnesylation. Down-regulation of Rho signaling by coexpression of dominant-negative Rho mutants (i.e RhoA, RhoB and Rac) impaired TNF-alpha driven E-selectin gene expression, indicating Rho signaling to be essential for transcriptional activation of the E-selectin gene. Inhibition of E-selectin expression by lovastatin gives rise to a significant reduction in TNF-alpha stimulated adhesion of colon carcinoma cells to HUVEC. Furthermore, low concentration of lovastatin (i.e., < or =1 microM) attenuated TNF-alpha induced tumor cell invasion in vitro. The data support the view that statins might be clinically useful in protection against E-selectin mediated metastasis.lld:pubmed
pubmed-article:14630701pubmed:languageenglld:pubmed
pubmed-article:14630701pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630701pubmed:citationSubsetIMlld:pubmed
pubmed-article:14630701pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630701pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630701pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630701pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630701pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:14630701pubmed:statusMEDLINElld:pubmed
pubmed-article:14630701pubmed:monthJanlld:pubmed
pubmed-article:14630701pubmed:issn1530-6860lld:pubmed
pubmed-article:14630701pubmed:authorpubmed-author:KainaBerndBlld:pubmed
pubmed-article:14630701pubmed:authorpubmed-author:KleinertHartm...lld:pubmed
pubmed-article:14630701pubmed:authorpubmed-author:FritzGerhardGlld:pubmed
pubmed-article:14630701pubmed:authorpubmed-author:NübelTobiasTlld:pubmed
pubmed-article:14630701pubmed:authorpubmed-author:DippoldWolfga...lld:pubmed
pubmed-article:14630701pubmed:issnTypeElectroniclld:pubmed
pubmed-article:14630701pubmed:volume18lld:pubmed
pubmed-article:14630701pubmed:ownerNLMlld:pubmed
pubmed-article:14630701pubmed:authorsCompleteYlld:pubmed
pubmed-article:14630701pubmed:pagination140-2lld:pubmed
pubmed-article:14630701pubmed:dateRevised2005-11-17lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:meshHeadingpubmed-meshheading:14630701...lld:pubmed
pubmed-article:14630701pubmed:year2004lld:pubmed
pubmed-article:14630701pubmed:articleTitleLovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates tumor cell adhesion.lld:pubmed
pubmed-article:14630701pubmed:affiliationUniversity of Mainz, Institute of Toxicology, Division of Applied Toxicology, Mainz, Germany.lld:pubmed
pubmed-article:14630701pubmed:publicationTypeJournal Articlelld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14630701lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14630701lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14630701lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:14630701lld:pubmed