Linked Life Data

14628906

Source:http://linkedlifedata.com/resource/pubmed/id/14628906

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-11-21
pubmed:abstractText
The recent interest in plasma nucleic acids has opened up many new promising possibilities for the noninvasive detection and monitoring of a variety of diseases. The discovery of tumor-derived DNA in the plasma of cancer patients has provided an alternative method for cancer detection, monitoring and prognostication, whereas the presence of fetal DNA in maternal plasma has revealed significant clinical potential for the prenatal diagnosis of fetal genetic diseases and pregnancy-associated complications. Further applications have been reported in transplantation, traumatology and acute medicine. Extending beyond plasma DNA, a new field of investigation has also been developed in the analysis of plasma RNA, which holds promise for noninvasive gene expression profiling. Biologically, future work will focus on the elucidation of the origin and clearance of circulating DNA, as well as the unexpected stability of circulating RNA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1473-7159
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
785-97
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Cell-free DNA and RNA in plasma as new tools for molecular diagnostics.
pubmed:affiliation
Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories. s020308@mailserv.cuhk.edu.hk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't